Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Structural characteristics and physiological lipid metabolism function: Fatty acid desaturase 2(FADS2), encoded by FADS2 gene, belongs to a family of fatty acid desaturases with multiple transmembrane bound dehydrogenases, and is widely located in the endoplasmic reticulum membrane structure of various metabolically active tissues. There is a significant difference between the enzyme and the cytoplasmic soluble metabolic regulator. Its molecular structure contains N-terminal cytochrome b5-like domain, and there are conservative histidine-rich catalytic motifs in the transmembrane segment, so it does not have an independent soluble effect functional module. As a metabolic regulatory protein of endoplasmic reticulum microsomes, FADS2 can catalyze the introduction of carbon-carbon double bonds into fatty acyl carbon chains under physiological steady-state conditions and participate in the synthesis and modification of unsaturated fatty acids. When the functional reserve of membrane-bound desaturase is insufficient, the body is prone to metabolic abnormalities such as the disorder of polyunsaturated fatty acid synthesis and the imbalance of lipid components in cell membrane, and FADS2 can play an effective metabolic buffering role and maintain the dynamic balance of long-chain lipid biosynthesis in various high metabolic activity tissues. The components of fatty acyl substrates in different tissues are obviously heterogeneous, and the metabolic system of multicellular tissues needs to rely on various membrane-located desaturases to maintain the overall lipid metabolism steady state. Among them, FADS2 anchored in endoplasmic reticulum membrane can continuously bind fatty acyl metabolic substrates, inhibit the abnormal deviation of tissue lipid spectrum, and ensure the stability of local cell membrane lipid structure and function.
Mutation effect, regulation mechanism and research value: FADS2 gene mutation can change the catalytic binding affinity of protein to substrate, and trigger abnormal remodeling of polyunsaturated lipid metabolism pattern in tissues. In the fatty acid desaturase family, only FADS2 has dual core functions of fatty acyl substrate processing and modification and endoplasmic reticulum membrane anchoring, and no other family members can completely reproduce its unique biological characteristics. The expression abundance of FADS2 is highly compatible with the overall lipid metabolism state of the organism, and it is an important research target to study the function of multiple transmembrane desaturases and analyze the regulation mechanism of polyunsaturated fatty acid synthesis. At the level of molecular regulation, FADS2 is stably embedded in the lipid bilayer of endoplasmic reticulum, and the catalytic reaction is completed by specifically binding to metabolic substrates, and this process will not induce continuous activation of intracellular signal cascade. Different from pure cytoplasmic soluble metabolic enzymes, its unique endoplasmic reticulum microsomal membrane localization enables it to simultaneously mediate the synthesis of polyunsaturated lipids and the specific molecular recognition of lipid substrates. When the function of FADS2 protein is defective or its expression is down-regulated, the biosynthesis process of long-chain polyunsaturated fatty acids in tissues will be significantly disordered, and the buffering and regulating ability of local lipid metabolism will be greatly weakened, which further confirms the important scientific research value of FADS2 in the basic research of membrane-bound desaturase family.
Fig. 1 Predicted membrane‑topology schematic of FADS2 within endoplasmic reticulum. Conserved histidine‑rich catalytic motifs (HIS I‑III) and structural segments support desaturase catalytic function.1
The biological functions of transmembrane FADS2 desaturase protein are focused on sustained fatty-acyl substrate engagement and lipid-biosynthesis coordination:
Creative Biolabs offers purified FADS2 membrane samples produced under unified preparation workflows, including full-length FADS2 constructs and isolated catalytic-domain variants. Truncated domain fragments cannot support complete fatty-acyl-substrate-processing behaviours, while full-length constructs suit research focused on microsomal lipid-substrate interaction and endoplasmic-reticulum-membrane anchoring functional observation. All batches receive uniform quality screening. Functional relevant observation may only be carried out with full-length samples under simulated microsomal-membrane microenvironment setups. Consistent structural features are preserved across batches to support comparative laboratory analysis across separate test groups. Full-length FADS2 samples retain intact histidine-rich catalytic-motif conformation after standardized purification, which supports reliable detection of weak and transient enzyme-substrate contacts for comparative functional analysis.
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Creative Biolabs provides adjustable FADS2 expression cell research models with varied expression levels, applicable to structural observation of multi-pass membrane-bound desaturase proteins and research into lipid-substrate molecular interaction. Sample evaluation includes sustained target expression detection and preliminary substrate-interaction observation, enabling side-by-side comparison of enzymatic catalytic behaviours under differing expression abundances. These cell systems can pair with diverse laboratory analysis schemes to track changes in substrate-processing efficiency alongside shifting target protein levels.
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Anti-FADS2 recombinant antibodies are generated via standardized protein preparation workflows, compatible with routine laboratory detection techniques for endoplasmic-reticulum-membrane localization mapping and identification of lipid-metabolic multi-protein molecular complexes. The antibody series can work alongside common laboratory detection reagents to realize multi-dimensional observation of target distribution within lipid-metabolism-rich tissue samples.
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Beyond catalog products, Creative Biolabs offers specialized custom services for FADS2 research:
FADS2 might act as a multi-pass endoplasmic-reticulum-bound desaturase and participate in fatty-acyl substrate catalysis to modulate long-chain polyunsaturated-fatty-acid biosynthesis.
FADS2 expression status could alter lipid-substrate catalysis efficiency and local polyunsaturated-lipid balance, serving as a major regulatory mediator of tissue lipid-metabolic biological processes.
No, all FADS2 related products and services are strictly for research use only, and cannot be applied in clinical workflows. All material designs and functional tests are optimized exclusively for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full-length FADS2 membrane protein, target-specific recombinant antibodies and tunable expression cell research models, supporting research on membrane lipid homeostasis and microsomal-desaturase-mediated polyunsaturated-fatty-acid generation.
Laboratory observation schemes may include enzyme-substrate interaction related tests to analyse catalytic-associated behaviors under simulated microsomal-membrane environments.
