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FAXC

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Background

The FAXC gene is located in the 6p25.1 region of the human chromosome and encodes the FAXC protein. This protein belongs to the protein family containing the C2 domain. FAXC is an intracellular protein mainly expressed in the nervous system and skeletal muscle tissues. Its molecular weight is approximately 40 kDa and it participates in biological processes such as cell adhesion, signal transduction, and dynamic regulation of the cytoskeleton. As an important regulatory factor for cell connection and communication, FAXC plays a crucial role in neural development and maintenance of muscle function. This gene has multiple single nucleotide polymorphism sites. Some missense variations can affect the subcellular localization of the protein or the efficiency of interaction with other molecules, thereby altering its physiological function. Additionally, abnormal expression levels of FAXC are associated with the risk of certain neuro-psychiatric diseases and muscle-related disorders, suggesting its potential impact in disease occurrence and development. Therefore, FAXC is gradually becoming a research hotspot in the fields of neuroscience and muscle biology. The analysis of its variations provides an important entry point for understanding the structure-function relationship and molecular mechanisms related to individual differences.

Fig.1 Predicted metaxin and FAXC: Topology and complexes. (OA Literature)Fig. 1 Predicted structures of metaxin and FAXC: Topology and MTX1/MTX2/FAXC complexes.1

Function of FAXC Protein: An Important Player in Cell Connection and Signal Regulation

The functional scope of FAXC is quite extensive and is still expanding:

  • Cell adhesion and cytoskeleton regulation: FAXC is involved in the processes of cell adhesion and dynamic rearrangement of the cytoskeleton, influencing cell morphology maintenance and migration ability.
  • Signal transduction regulation: This protein mediates the transmission of various intracellular signaling pathways, playing a particularly important role in nerve and muscle tissues.
  • Genetic variation and functional differences: Natural variations in the coding regions of genes can alter the integrity of protein domains or the interaction interfaces, thereby affecting their binding efficiency and regulatory activity.
  • Study on protein structure-function relationship: The structural analysis of different variants of FAXC is helpful in understanding the molecular recognition mechanism and the basis of its functional diversity.

FAXC Membrane Protein Product

Creative Biolabs offers a series of high-quality FAXC membrane protein products, which are suitable for structural analysis and functional research. Relying on the independently developed MemDX™ recombinant membrane protein technology platform, FAXC proteins can be produced through various expression systems, including virus-like particle (VLP) systems and in vitro prokaryotic expression systems. These rigorously validated protein products, such as MemDX™ recombinant human FAXC membrane protein (in virus-like particle form) and human FAXC protein derived from the eukaryotic expression system, can be used in applications such as ELISA, antibody screening and identification, binding experiments, and functional analysis. These products provide reliable tool support for researchers to analyze the interaction network and activity regulation mechanism of FAXC.

FAXC Protein Product

Not finding the membrane protein product you need? Contact us to start your one-stop custom service!

FAXC Stable Cell Line Product

Constructing a robust cell model is useful for the study of FAXC expression and function. As a single-pass membrane protein that may play a role in axonal development, FAXC can be investigated in a cellular context to examine its expression, localization, and potential molecular interactions. Creative Biolabs offers customized FAXC stable expression cell models expressing wild-type FAXC. These cell models are suitable for studies of FAXC expression and membrane localization, protein-protein interaction analysis, binding studies, and related functional investigations, providing a reliable and reproducible experimental platform for exploring the molecular properties and biological role of FAXC. Our technology supports stable target expression and appropriate cellular localization, facilitating further research on FAXC biology.

FAXC Stable Cell Line Product

Not finding the stable cell line product you need? Contact us to start your one-stop custom service!

FAXC Recombinant Antibody Product

Creative Biolabs offers highly specific recombinant antibodies targeting FAXC, which are prepared using advanced recombinant antibody technology. Compared to traditional polyclonal antibodies, these recombinant antibodies demonstrate superior performance in terms of specificity, sensitivity, and batch-to-batch consistency. Our FAXC recombinant antibodies support various application scenarios, including Western Blot (WB), enzyme-linked immunosorbent assay (ELISA), flow cytometry (FCM), immunofluorescence (IF), immunocytochemistry (ICC), immunohistochemistry (IHC), and immunoprecipitation (IP), and can be used to distinguish the expression level differences of different FAXC variants, detect their localization distribution in specific tissues or cells, and study the interaction relationships between proteins. These antibodies provide reliable detection tool support for the structural analysis, functional research, and genetic variation analysis of FAXC.

FAXC Recombinant Antibody Product

Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!

Product Features

  • Diverse expression systems: Offer multiple recombination expression platforms, allowing for the selection of the appropriate system for FAXC membrane protein preparation based on research requirements.
  • Extensive application verification: The product is applicable to various detection scenarios such as ELISA, antibody screening, binding experiments, protein interaction analysis, Western Blot, immunofluorescence, and immunohistochemistry.
  • Good batch-to-batch consistency: Through strict production process control, ensure the stable performance of each batch of products, and make the experimental results reliable and repeatable.
  • Flexible customization service: Supports personalized customization for specific FAXC mutants, fusion tags or expression patterns, meeting the needs of differentiated research.

Custom FAXC Membrane Protein and Antibody Discovery Services

In addition to the standard products, Creative Biolabs also offers specialized customized services for FAXC. FAXC has several variants with distinct functional differences, which pose specific requirements for protein expression, antigen design, and functional validation. Leveraging our technology platform, we can assist you in achieving the following:

  • Customized membrane protein preparation: Personalized expression, purification and property identification are carried out for different variants.
  • Customized antibody development: From antigen design to antibody engineering (monoclonal antibodies, polyclonal antibodies, recombinant antibodies), supporting variant discrimination or common epitope recognition.
  • Stable cell model construction: Construct stable cell models that express specific variants for functional comparison studies.
  • Development of functional testing methods: Design and conduct activity assays, combined analysis, and evaluation of functional differences of variants.

Frequently Asked Questions (FAQ)

  1. What is the main function of the FAXC gene?

    The FAXC gene is mainly involved in cell adhesion, signal transduction, and dynamic regulation of the cell skeleton. It plays a significant role in neural development and the maintenance of muscle function. The activity of this protein is influenced by genetic variations, and different variants have differences in binding efficiency and regulatory capacity, making it a good model for studying the relationship between membrane protein structure and function.

  2. Why is FAXC an important research subject?

    FAXC exhibits various natural genetic variations, which can lead to alterations in the integrity of protein domains or a decrease in interaction capabilities. Studying the polymorphisms of FAXC is helpful for understanding the structure-function relationship of membrane proteins, the molecular mechanism of differences in signal regulation among individuals, and the regulatory factors of protein activity.

  3. Are Creative Biolabs'FAXC products suitable for clinical applications?

    No. All FAXC products and services of Creative Biolabs are for research purposes only and cannot be used for any clinical diagnosis, prevention, treatment or cure of any disease.

  4. What types of FAXC products does Creative Biolabs offer?

    We provide a variety of product types, including recombinant FAXC membrane proteins, stable cell models expressing FAXC, high-quality recombinant FAXC antibodies, and comprehensive customized services.

Reference
  1. Oakley, Aaron J. "Hidden glutathione transferases in the human genome." Biomolecules 13.8 (2023): 1240. Under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/biom13081240
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