Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
F-box and WD repeat domain containing 7 (FBXW7) is a cytoplasmic substrate-recognition adaptor encoded by FBXW7 gene, broadly expressed across somatic cell populations, localized to cytoplasmic and perinuclear membrane compartments. Distinct from other F-box paralogs, FBXW7 relies on conserved WD40 repeat domains to recognize phosphorylated oncogenic substrates, while simultaneously mediating substrate recruitment to SCF ubiquitin ligase complexes to trigger proteasomal degradation cascades. Under resting physiological immune states, basal FBXW7 recognition activity sustains balanced turnover of proliferative mediators without disrupting normal cell cycle progression. Upon oncogenic activation and metabolic stress, accumulated phosphorylated target substrates are captured by FBXW7 adaptor modules, facilitating ubiquitination and downstream clearance of proliferation-driving factors. Unlike broad-spectrum ubiquitin adaptors with general protein turnover roles, FBXW7 bears specialized tumor-suppressive substrate recognition functions that cannot be fully compensated by other F-box family members, linking substrate phosphorylation directly to oncogene degradation pathways. Loss of functional FBXW7 severely blunts oncoprotein clearance and accelerates aberrant cell proliferation, while sustained FBXW7 adaptor activity restrains malignant transformation, establishing FBXW7 as a core research target for ubiquitin proteolysis biology and anti-tumor compound screening.
FBXW7 executes core substrate-recruiting ubiquitin adaptor function within cytoplasmic membrane-associated complexes, utilizing conserved WD40 substrate-binding pockets to power selective capture of phosphorylated proliferative target proteins. Conserved phospho-peptide recognition motifs exclusively bind oncogenic degradation substrates, separating its substrate spectrum from housekeeping ubiquitin adaptors distributed throughout cellular compartments. FBXW7-mediated substrate shuttling bridges intracellular kinase signaling and proteasomal degradation machinery, balancing proliferative signal intensity and oncoprotein turnover efficiency according to cellular stress load. FBXW7 participates in extensive physiological processes including cell cycle checkpoint control, proliferative factor clearance and tumorigenesis suppression. Deficient FBXW7 adaptor capacity disrupts oncogenic protein surveillance and impairs intrinsic growth restriction mechanisms. Therefore, FBXW7 represents a pivotal research target for SCF complex carrier study and anti-proliferative therapeutic screening.
Fig. 1 Circ-FBXW7 suppresses colorectal cancer proliferation and invasion via inhibiting NEK2/mTOR and upregulating PTEN.1
The biological functions of FBXW7 are focused on phosphorylated substrate capture, SCF ligase recruitment and cell cycle signal control:
Creative Biolabs offers high-quality FBXW7 proteins through optimized expression systems, including full-length ubiquitin adaptor and isolated WD40 substrate-binding domain variants. These products retain native phospho-substrate recognition biological activity, suitable for ubiquitin complex interaction assays and anti-tumor modulator screening. All FBXW7 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered FBXW7 stable cell lines, including overexpression and blank control models. These cell lines are optimized for ubiquitin adaptor expression profiling and oncogenic degradation signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting FBXW7 are developed via advanced antibody engineering technologies, with no cross-reactivity with other F-box family ubiquitin adaptors. These antibodies are validated for cytoplasmic membrane compartment localization detection and multi-tissue expression profiling, and can be combined with ubiquitin marker detection reagents to analyze complete SCF substrate complexes in proliferative cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for FBXW7 research:
FBXW7 is an F-box ubiquitin adaptor that recognizes phosphorylated oncogenic substrates and mediates their proteasomal degradation to restrict cell proliferation.
FBXW7 acts as a critical link between kinase-mediated substrate phosphorylation and tumor-suppressive protein clearance, governing cellular growth surveillance.
No, all FBXW7 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length FBXW7 ubiquitin adaptor proteins, isoform-specific detection antibodies and custom stable cell lines for tumor suppressor research.
FBXW7 proteins are validated via phospho-oncoprotein substrate binding functional testing.
