Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Fc receptor like 5 (FCRL5) is an immunoglobulin superfamily transmembrane receptor encoded by the FCRL5 gene, selectively expressed on mature and memory B cell subsets, localized exclusively to plasma membrane lipid bilayers. Distinct from canonical Fc gamma receptors, FCRL5 carries tandem extracellular Ig domains paired with dual intracellular inhibitory and stimulatory signaling motifs, balancing B cell proliferative and differentiation signals upon immune complex exposure. Under steady lymphoid homeostasis, basal FCRL5 expression restrains aberrant B cell activation to limit autoantibody production. Upon foreign antigen challenge, modulated FCRL5 signaling shapes germinal center progression and memory lymphocyte formation. Unlike broadly distributed Fc receptors, FCRL5 bears B cell lineage-specific immune tuning functions that cannot be fully substituted by other FCRL paralogs, linking immune complex recognition directly to humoral differentiation pathways. Loss of functional FCRL5 distorts memory B cell development and elevates autoreactive antibody risk, while altered receptor signaling reshapes antibody repertoire formation, establishing FCRL5 as a core research target for B cell membrane receptor biology and autoimmune modulator screening.
FCRL5 executes dual-signaling immune receptor function embedded within B cell surface bilayers, utilizing multiple extracellular Ig-like domains to bind immunoglobulin-containing immune complexes. Conserved ligand binding pockets separate its substrate spectrum from activating-only Fc receptors distributed across myeloid cells. FCRL5-mediated immune complex sensing bridges extracellular antigen complex detection and intracellular differentiation transcriptional programs, balancing B cell clonal expansion and memory cell formation according to antigen load. FCRL5 participates in germinal center maturation, memory B cell generation and autoreactive immune restraint. Deficient FCRL5 expression disrupts ordered humoral immune maturation. Therefore, FCRL5 represents a pivotal research target for FCR superfamily receptor study and autoimmunity compound screening.
Fig. 1 FcRL5 is a signature marker of atMBC subsets during naïve B cell differentiation, and marks memory B cells with robust antibody-secreting capacity upon in vitro stimulation.1
The biological functions of FCRL5 are focused on immunoglobulin complex binding, dual intracellular signal integration and humoral control:
Creative Biolabs offers high-quality FCRL5 proteins through optimized expression systems, including full-length transmembrane receptor and isolated extracellular Ig domain variants. These products retain native immune complex binding biological activity, suitable for receptor-ligand interaction and humoral modulator screening. All FCRL5 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered FCRL5 stable cell lines, including overexpression and blank control models. These cell lines are optimized for FCRL receptor profiling and B cell differentiation signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting FCRL5 are developed via advanced antibody engineering technologies, with no cross-reactivity with other FCR family receptors. These antibodies are validated for B cell plasma membrane localization detection and lymphoid tissue expression profiling, and can be combined with B lineage marker reagents to analyze complete immune complex receptor complexes in primary B cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for FCRL5 research:
FCRL5 is a B cell Fc-like receptor binding immune complexes to integrate dual inhibitory/co-stimulatory signals regulating B cell maturation.
FCRL5 links immune complex sensing to memory B cell development and autoreactive immune suppression.
No, all FCRL5 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length FCRL5 membrane receptors, isoform-specific detection antibodies and custom stable cell lines for humoral immunity research.
FCRL5 proteins are validated via immune complex binding functional testing.
