Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Fibroblast growth factor 19 (FGF19) is a secreted endocrine polypeptide encoded by the FGF19 gene, composed of conserved FGF core growth factor domain and C-terminal endocrine regulatory motif, and acts as a circulating ligand subunit for hepatic FGFR-Klotho receptor heterodimer complexes. FGF19 is widely secreted from intestinal epithelial cell populations, serving as a soluble signaling scaffold mediating hepatic receptor heterodimer formation and downstream metabolic kinase recruitment upon luminal bile acid stimulation.
FGF19 exerts its biological effects through stable heterodimeric assembly with hepatic FGFR-Klotho receptor chains, a mechanism that modulates ligand binding stability and intracellular hepatic metabolic signal cascade activation efficiency. Unlike tissue-restricted FGF ligands, FGF19 cannot trigger full metabolic signal output without co-receptor complex formation and relies on receptor dimerization to initiate complete feedback signaling; it recruits cytoplasmic signal mediators to assembled hepatic receptor complexes, uncoupling intestinal bile acid sensing from intracellular hepatic metabolic transcription factor activation and sustaining persistent systemic metabolic response signals. This dual regulation modulates the intensity of bile acid-triggered hepatic feedback responses after intestinal metabolite absorption, fine-tuning local hepatocyte lipid turnover and metabolic mediator secretion levels, while sustained abnormal FGF19-mediated endocrine signaling drives disrupted bile acid homeostasis and systemic metabolic lesions. FGF19 participates in key physiological and pathological processes including intestinal-hepatic bile acid feedback, systemic energy balance regulation, nutrient-mediated hepatic remodeling and chronic metabolic syndrome disorders. Dysregulation of FGF19 expression or receptor heterodimerization capacity is closely associated with unbalanced bile acid circulation and impaired systemic metabolic surveillance, making FGF19 a crucial research target for endocrine FGF signaling, intestinal-hepatic axis physiology and metabolic disease research.
Fig. 1 Enteric bile acids induce FGF19 expression; circulating FGF19 activates hepatic FGFR4/β-Klotho complex, triggering ERK/JNK/PI3K/JAK cascades to repress bile acid synthesis, regulate glucose/lipid metabolism and modulate hepatocyte survival & proliferation.1
The biological functions of FGF19 are focused on FGFR-Klotho receptor heterodimerization, endocrine metabolic signal propagation and intestinal-hepatic axis balance:
Creative Biolabs offers high-purity FGF19 proteins through optimized heterologous expression systems, including full-length FGF19 and isolated core growth factor domain variants with modified endocrine motif status. These products retain native conformational characteristics and FGFR-Klotho heterodimer binding activity, suitable for intestinal-hepatic endocrine signaling research, receptor complex interaction detection, and small molecule metabolic regulator screening for metabolic syndrome research. All FGF19 proteins undergo strict quality control, including purity analysis and biological activity validation to ensure biological function.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered FGF19 stable cell lines, including overexpressing and knockdown models in intestinal epithelial and hepatic cell models. These cell lines are optimized for studying FGF19-mediated FGFR-Klotho receptor heterodimer assembly mechanisms, endocrine metabolic signal cascade dynamics, and metabolic regulatory compound sensitivity. Each cell line undergoes stringent validation, including stable expression detection and functional integrity verification.
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High-specificity recombinant antibodies targeting FGF19 are developed via advanced antibody engineering technologies, with no cross-reactivity with other endocrine FGF family ligands. These antibodies are validated for multiple applications, including immunofluorescence for FGF19 intracellular secretory localization, Western blot for expression analysis, and co-immunoprecipitation for FGF19-receptor complex research, enabling precise analysis of FGF19 expression, subcellular localization and functional regulation.
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Beyond catalog products, Creative Biolabs offers specialized custom services for FGF19 research:
FGF19 is a secreted endocrine fibroblast growth factor that forms heteromeric complexes with hepatic FGFR-Klotho co-receptors to modulate bile acid feedback signal amplitude, balance intestinal-hepatic lipid turnover dynamics, and mediate systemic energy homeostasis upon intestinal bile acid stimulation.
FGF19 is the core endocrine regulator of intestinal-hepatic bile acid feedback and systemic metabolic homeostasis, and its dysregulation is associated with unbalanced lipid turnover and chronic metabolic syndrome lesions. It is a critical target for endocrine FGF and metabolic disease research.
No, all FGF19 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include FGF19 proteins (full-length, core growth factor domain variants), specific recombinant antibodies, and custom stable intestinal epithelial cell lines, supporting intestinal-hepatic endocrine and metabolic research.
FGF19 proteins are validated by FGFR-Klotho heterodimer binding assays and hepatic metabolic signal regulation verification to ensure native regulatory function in intestinal-hepatic axis research.
