Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Growth arrest specific 6 (GAS6) is a secreted vitamin K-modified extracellular ligand encoded by GAS6 gene, secreted by stromal and myeloid cell populations, localized to extracellular matrix and cell surface membrane interfaces. Distinct from other secreted growth factors, GAS6 relies on gamma-carboxylated N-terminal domains to bridge phosphatidylserine externalized on apoptotic debris and cell-surface TAM receptor complexes, while simultaneously transmitting anti-inflammatory signaling cascades to restrain myeloid inflammatory activation. Under resting physiological immune states, basal GAS6 secretion sustains steady efferocytic clearance of apoptotic cells without inducing overt tissue immune suppression. Upon tissue injury and cellular apoptosis, accumulated extracellular GAS6 forms crosslinking complexes bridging dead cell membranes and macrophage TAM receptors, facilitating downstream anti-inflammatory cytokine release and inflammatory resolution programs. Unlike broad-spectrum secreted trophic factors with general proliferative roles, GAS6 bears specialized efferocytosis and immune-resolving functions that cannot be fully compensated by other TAM ligand family members, linking apoptotic debris recognition directly to tissue anti-inflammatory homeostatic pathways. Loss of functional GAS6 severely blunts apoptotic cell clearance and amplifies persistent tissue inflammatory responses, while sustained GAS6 ligand activity restrains excessive myeloid inflammation, establishing GAS6 as a core research target for secreted immunomodulatory ligand biology and anti-inflammatory compound screening.
GAS6 executes core TAM receptor bridging function within extracellular matrix compartments, utilizing conserved gamma-carboxylated glutamic acid motifs to power dual recognition of phosphatidylserine lipid moieties and TAM receptor extracellular domains. Conserved ligand interaction regions exclusively engage TAM receptor ectodomains, separating its binding spectrum from unrelated secreted growth factors distributed across tissue microenvironments. GAS6-mediated molecular bridging bridges apoptotic debris labeling and macrophage immune receptor activation, balancing efferocytic clearance efficiency and tissue inflammatory response magnitude according to local apoptotic cell load. GAS6 participates in extensive physiological processes including apoptotic cell efferocytosis, myeloid inflammatory suppression and tissue repair homeostasis. Deficient GAS6 secretion disrupts silent clearance of dying cells and impairs systemic inflammatory resolution capacity. Therefore, GAS6 represents a pivotal research target for secreted vitamin K-dependent ligand study and inflammation-resolving therapeutic screening.
Fig. 1 GAS6 deficiency suppresses macrophage efferocytosis and induces inflammatory cartilage erosion in obese osteoarthritis.1
The biological functions of GAS6 are focused on dual lipid-receptor binding, efferocytic clearance and myeloid inflammatory control:
Creative Biolabs offers high-quality GAS6 proteins through optimized expression systems, including full-length secreted ligand and isolated receptor-binding domain variants. These products retain native TAM receptor crosslinking biological activity, suitable for extracellular ligand-receptor interaction assays and inflammation-resolving modulator screening. All GAS6 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered GAS6 stable cell lines, including overexpression and blank control models. These cell lines are optimized for secreted ligand expression profiling and TAM receptor inflammatory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting GAS6 are developed via advanced antibody engineering technologies, with no cross-reactivity with other TAM ligand family proteins. These antibodies are validated for extracellular matrix and cell surface ligand localization detection and multi-tissue secretion profiling, and can be combined with TAM receptor detection reagents to analyze complete GAS6 immune signaling complexes in myeloid cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for GAS6 research:
GAS6 is a vitamin K-dependent secreted ligand that crosslinks apoptotic cells and macrophage TAM receptors to drive efferocytosis and suppress inflammation.
GAS6 acts as a critical link between apoptotic debris recognition and tissue inflammatory resolution, governing homeostatic tissue immune balance.
No, all GAS6 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length GAS6 secreted ligand proteins, isoform-specific detection antibodies and custom stable cell lines for efferocytosis and inflammation research.
GAS6 proteins are validated via dual phosphatidylserine-TAM receptor binding functional testing.
