Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Gastrin releasing peptide receptor (GRPR) is a seven-transmembrane Gq-coupled GPCR encoded by the GRPR gene, expressed on neuroendocrine, epithelial and transformed tumor cells, localized exclusively to plasma lipid bilayers. Distinct from other bombesin family receptors, GRPR selectively binds gastrin-releasing peptide ligands to trigger intracellular calcium mobilization and proliferative transcriptional cascades. Under physiological neuroendocrine balance, basal GRPR activity sustains moderate gastrointestinal hormone secretion without aberrant cell growth. Upon ligand overabundance or malignant transformation, sustained GRPR signaling amplifies proliferative and migratory programs driving tumor expansion. Instead of ubiquitous peptide receptors, GRPR bears neuroendocrine tissue-specific proliferative regulatory functions that cannot be fully substituted by related bombesin receptors, linking neuropeptide ligand binding directly to tumor growth pathways. Loss of balanced GRPR signaling restrains proliferative potential, while receptor overexpression accelerates neoplastic progression, establishing GRPR as a core research target for neuropeptide GPCR biology and anti-proliferative compound screening.
GRPR executes Gq-mediated signal transduction function embedded within cell surface membranes, utilizing extracellular ligand-binding pockets to capture gastrin-releasing peptide neuropeptides. Conserved binding cavities distinguish its ligand selectivity from other bombesin receptor paralogs distributed across neural tissue. GRPR-mediated peptide sensing bridges extracellular neuropeptide stimulation and intracellular calcium-dependent proliferative signaling, balancing neuroendocrine secretion and cell growth according to ligand concentration. GRPR participates in gastrointestinal hormone release, neural sensory signaling and neuroendocrine tumor proliferation. Deficient GRPR expression blunts peptide-driven proliferative responses. Therefore, GRPR represents a pivotal research target for bombesin GPCR study and neuroendocrine anti-tumor compound screening.
Fig. 1 Structural construction of GRPR-targeted ProCA1 fluorescent probes and specific binding interaction between targeting peptide and cell membrane GRPR receptor.1
The biological functions of GRPR are focused on neuropeptide ligand binding, Gq calcium signaling and cell growth control:
Creative Biolabs offers high-quality GRPR proteins through optimized expression systems. These products retain native neuropeptide binding and Gq signaling biological activity, suitable for ligand-receptor interaction and anti-tumor modulator screening. All GRPR proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered GRPR stable cell lines, including overexpression and blank control models. These cell lines are optimized for bombesin GPCR profiling and calcium proliferative signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting GRPR are developed via advanced antibody engineering technologies, with no cross-reactivity with other bombesin GPCR family members. These antibodies are validated for neuroendocrine cell membrane localization detection and tumor tissue expression profiling, and can be combined with neuropeptide marker reagents to analyze complete GRP-GRPR signaling complexes in neuroendocrine cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for GRPR research:
GRPR is a Gq-coupled GPCR binding gastrin-releasing peptide to trigger calcium mobilization and drive neuroendocrine cell proliferation.
GRPR links neuropeptide hormone signaling to neuroendocrine tumor growth, serving as a tumor biomarker and therapeutic target.
No, all GRPR products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length GRPR GPCR proteins, isoform-specific detection antibodies and custom stable cell lines for neuroendocrine tumor research.
GRPR proteins are validated via gastrin-releasing peptide ligand binding and calcium signal functional testing.
