Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Insulin like growth factor 2 receptor (IGF2R) is a single pass transmembrane receptor encoded by IGF2R gene. This protein localizes to plasma membrane and endosomal membrane compartments of many cell types. IGF2R contains a very large extracellular region composed of multiple repeated structural domains, a single transmembrane helix and a sizable intracellular cytoplasmic tail. Extracellular repeated domains project outward toward extracellular milieu, while cytoplasmic tail faces endosomal or cytoplasmic side and carries sequence motifs responsible for vesicle trafficking signals. Newly synthesized IGF2R is processed within Golgi compartments. A portion of protein pool cycles continuously between cell surface and endosomal membrane compartments via vesicle transport machinery. Different cell populations maintain distinct steady‑state distribution ratios between plasma membrane and endosome. Proper folding of repeated extracellular modules is required for normal ligand engagement and subcellular cycling behaviour.
The large extracellular domain array of IGF2R can bind multiple distinct soluble ligand molecules. After ligand capture at cell surface, receptor‑ligand assemblies can be internalized through vesicle formation. Sequence motifs on intracellular cytoplasmic tail interact with cytoplasmic sorting machineries to guide receptor and bound cargo toward defined endosomal compartments. Within endosomal environments, altered biochemical conditions may promote dissociation between receptor and bound ligand. Receptor molecules can be recycled back to plasma membrane, while released ligands are directed toward subsequent intracellular processing routes. Other receptor proteins cannot fully reproduce the broad ligand‑binding spectrum and dual compartment cycling properties of IGF2R. Variation in IGF2R abundance changes total capacity for ligand capture and subsequent endosomal sorting. Sequence alteration within extracellular repeated domains may disturb ligand recognition, while mutation of cytoplasmic sorting motifs interferes with normal vesicle‑driven receptor trafficking.
Fig. 1 Schematic architecture of transmembrane IGF2R (CIMPR). The receptor possesses large extracellular domains for ligand recognition, and cytoplasmic motifs that mediate vesicular sorting events during intracellular trafficking.1
The biological functions of IGF2R are focused on multiligand molecular recognition, ligand‑receptor complex internalization and endosomal compartment sorting:
Creative Biolabs offers purified IGF2R membrane samples via standardized preparation workflows, including full length IGF2R constructs and isolated extracellular structural variants. Isolated extracellular fragments may not support complete multiligand binding and cytoplasmic sorting‑motif related behaviours, while full length constructs may be suited for multiligand receptor recognition and vesicle‑sorting‑associated molecular research. All samples receive routine quality screening, and functional relevant observation may only be carried out with full length samples under simulated membrane environments. All sample batches follow unified processing standards to maintain consistent structural features for comparative laboratory analysis across separate test groups.
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Creative Biolabs provides adjustable IGF2R expression cell models with varied expression levels, applicable to transmembrane multiligand receptor structural characteristic observation and endosomal sorting related research. Sample evaluation includes sustained target expression detection and preliminary intermolecular interaction associated observation, which can support comparative analysis of receptor associated behaviours under different expression statuses. These cell systems can be matched with diverse laboratory analysis schemes to observe changes of ligand recognition efficiency under different target expression abundances.
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Antibody reagents targeting IGF2R are generated via mature protein preparation workflows, compatible with multiple routine laboratory detection methods for cellular localization profiling and molecular complex identification, to support systematic analysis of IGF2R distribution and receptor ligand associated molecular complexes across diverse laboratory research setups. The antibody series can cooperate with other common laboratory detection reagents to complete multi dimensional observation of target distribution inside tissue samples.
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Beyond catalog products, Creative Biolabs offers specialized custom services for IGF2R research:
IGF2R may function as a transmembrane multiligand receptor and participate in soluble ligand capture and endosomal vesicle‑based molecular sorting.
IGF2R expression status may influence multiligand binding and endosomal sorting capacity, serving as a major regulatory mediator of receptor‑trafficking related biological processes.
No, all IGF2R related products and services are strictly for research use only, not intended for clinical related operations. All material designs and functional tests are only optimized for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full length IGF2R membrane protein, target specific recombinant antibodies and adjustable expression cell research models, supporting multi‑ligand receptor and intracellular trafficking research.
Laboratory observation schemes may include multiligand receptor binding related tests to analyse receptor‑associated behaviours under simulated cellular environments.
