Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Interleukin 1 receptor antagonist (IL1RN) is a soluble secreted regulatory protein encoded by the IL1RN gene, produced by myeloid and stromal cell populations, localized to extracellular tissue microenvironments. Distinct from agonistic IL-1 cytokines, IL1RN competitively occupies cell-surface IL-1 receptors without initiating downstream inflammatory signal cascades, neutralizing IL-1α/β agonist bioavailability. Under resting tissue conditions, basal IL1RN secretion maintains balanced inflammatory tone without full immune suppression. Upon tissue injury or pathogen challenge, elevated IL1RN production limits excessive IL-1-driven pro-inflammatory mediator release to resolve local immune responses. Unlike broad-spectrum anti-inflammatory factors, IL1RN carries selective IL-1 pathway inhibitory functions that cannot be fully compensated by other cytokine antagonists, linking receptor competitive binding directly to inflammatory resolution pathways. Loss of functional IL1RN amplifies IL-1-mediated tissue inflammation and increases autoimmune susceptibility, while sustained antagonist secretion restrains inflammatory tissue damage, establishing IL1RN as a core research target for cytokine regulatory protein biology and anti-inflammatory compound screening.
IL1RN executes competitive receptor antagonist function within extracellular compartments, utilizing conserved IL-1 receptor binding folds to occupy receptor ligand pockets without triggering signal transduction. Conserved receptor interaction domains exclusively target IL-1 receptor ectodomains, separating its binding spectrum from agonistic interleukin ligands. IL1RN-mediated competitive blockade bridges extracellular cytokine equilibrium and intracellular inflammatory transcriptional restraint, balancing IL-1 agonist activity and tissue injury severity according to inflammatory stimulus load. IL1RN participates in acute injury resolution, autoimmune tissue protection and mucosal immune balance. Deficient IL1RN secretion removes physiological IL-1 pathway braking mechanisms. Therefore, IL1RN represents a pivotal research target for interleukin antagonist study and autoimmunity compound screening.
Fig. 1 IL-1 superfamily receptor-ligand interaction modes, with panel E illustrating competitive inhibition of IL-1β inflammatory signaling by IL1RN (IL-1Ra).1
The biological functions of IL1RN are focused on receptor antagonism, IL-1 pathway suppression and tissue immune control:
Creative Biolabs offers high-quality IL1RN proteins through optimized expression systems. These products retain native competitive receptor blockade biological activity, suitable for cytokine receptor interaction and anti-inflammatory modulator screening. All IL1RN proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered IL1RN stable cell lines, including overexpression and blank control models. These cell lines are optimized for cytokine antagonist profiling and IL-1 inflammatory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting IL1RN are developed via advanced antibody engineering technologies, with no cross-reactivity with IL-1α/β agonistic cytokines. These antibodies are validated for extracellular fluid localization detection and multi-tissue secretion profiling, and can be combined with IL-1 receptor detection reagents to analyze competitive antagonist-receptor complexes in inflammatory cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for IL1RN research:
IL1RN is a secreted interleukin-1 receptor antagonist that competitively blocks IL-1 receptors to suppress pro-inflammatory signaling.
IL1RN acts as the primary physiological brake for IL-1-mediated inflammation, critical for autoinflammatory and tissue injury research.
No, all IL1RN products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length IL1RN antagonist proteins, isoform-specific detection antibodies and custom stable cell lines for anti-inflammatory research.
IL1RN proteins are validated via competitive IL-1 receptor binding functional testing.
