Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Interleukin 15 receptor subunit alpha (IL15RA) is a single pass transmembrane cytokine receptor subunit encoded by IL15RA gene. This protein localizes to plasma membrane surface of multiple immune cell populations. IL15RA contains large extracellular cytokine binding domain, one transmembrane helix and a short intracellular cytoplasmic segment. Extracellular domain is exposed to extracellular milieu while cytoplasmic segment faces cell interior. Alternative transcript isoforms are generated, including secreted isoform variants lacking transmembrane region. Polypeptide translation and folding take place within secretory organelles, and properly folded full length isoform traffics toward plasma membrane. Different immune cell subtypes show variable IL15RA expression magnitude. Only correctly folded extracellular domain can accomplish high affinity cytokine ligand engagement, while mis folded polypeptide will be cleared by intracellular quality control machineries. Secreted isoform generation is controlled by transcript processing and can change total pool of soluble receptor molecules in extracellular compartments.
The extracellular domain of membrane bound IL15RA establishes high affinity physical contact with interleukin 15 cytokine molecules. This receptor subunit can present bound cytokine ligand toward other receptor subunits to assemble complete multi subunit cytokine receptor complexes. Short intracellular cytoplasmic segment possesses limited intrinsic signal triggering capacity on its own, and full downstream signal output depends on assembly with additional partnering receptor subunits. Secreted isoform variants can also bind soluble cytokine molecules inside extracellular compartments. Other cytokine receptor subunits cannot reproduce the high affinity interleukin 15 binding property provided by IL15RA. Variation in IL15RA abundance changes cellular capacity to capture and present corresponding cytokine ligand molecules. Sequence modification within extracellular ligand binding domain may reduce or abolish interleukin 15 binding affinity, while alteration of cytoplasmic segment sequence influences intracellular molecular interactions after multi subunit complex formation. Shifts in the ratio between membrane bound and secreted isoform can modify overall cytokine sequestration behaviour in local extracellular environments.
Fig. 1 Schematic of IL15RA (IL‑15Rα)‑dependent cytokine trans‑presentation. Membrane‑located IL15RA captures IL‑15 ligand and presents it to assemble multi‑subunit receptor complex on adjacent effector cell surface.1
The biological functions of IL15RA are focused on high affinity interleukin 15 ligand capture, cytokine ligand presentation and multi subunit cytokine receptor complex assembly:
Creative Biolabs offers purified IL15RA membrane samples via standardized preparation workflows, including full length IL15RA constructs and isolated extracellular ligand binding domain variants. Isolated extracellular fragments may not support complete ligand presentation and multi subunit complex assembly related behaviours, while full length constructs may be suited for cytokine receptor subunit mediated ligand capture associated research. All samples receive routine quality screening, and functional relevant observation may only be carried out with full length samples under simulated membrane environments. All sample batches follow unified processing standards to maintain consistent structural features for comparative laboratory analysis across separate test groups.
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Creative Biolabs provides adjustable IL15RA expression cell models with varied expression levels, applicable to transmembrane cytokine receptor subunit structural characteristic observation and interleukin 15 ligand capture related research. Sample evaluation includes sustained target expression detection and preliminary intermolecular interaction associated observation, which can support comparative analysis of receptor associated behaviours under different expression statuses. These cell systems can be matched with diverse laboratory analysis schemes to observe changes of cytokine ligand binding efficiency under different target expression abundances.
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Antibody reagents targeting IL15RA are generated via mature protein preparation workflows, compatible with multiple routine laboratory detection methods for cellular localization profiling and molecular complex identification, to support systematic analysis of IL15RA distribution and cytokine receptor associated molecular complexes across diverse laboratory research setups. The antibody series can cooperate with other common laboratory detection reagents to complete multi dimensional observation of target distribution inside tissue samples.
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Beyond catalog products, Creative Biolabs offers specialized custom services for IL15RA research:
IL15RA may function as transmembrane cytokine receptor subunit and participate in high affinity interleukin 15 ligand capture and multi subunit receptor complex assembly.
IL15RA expression and isoform status may influence interleukin 15 ligand capture capacity, serving as a major regulatory mediator of cytokine receptor associated biological processes.
No, all IL15RA related products and services are strictly for research use only, not intended for clinical related operations. All material designs and functional tests are only optimized for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full length IL15RA membrane protein, target specific recombinant antibodies and adjustable expression cell research models, supporting interleukin 15 cytokine receptor biology research.
Laboratory observation schemes may include cytokine receptor subunit mediated ligand binding related tests to analyse receptor associated behaviours under simulated cellular environments.
