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- Antigen Species: Human
- Type: Membrane Protein
- Expression System: HEK293
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Datasheet
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- Antigen Species: Human
- Type: Membrane Protein
- Expression System: NS0
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Datasheet
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- Antigen Species: Human
- Type: Membrane Protein
- Expression System: HEK293
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Datasheet
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- Antigen Species: Human
- Type: Human IgG
- Expression System: CHO
- Application: ELISA, WB, IHC, FCM, IP, IF
- Official Symbol: IL17RB
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Datasheet
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
IL-17A, members of the IL-17 family include IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. All members of the IL-17 family have a similar protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape, yet they have no sequence similarity to any other known cytokines. Phylogenetic analysis reveals that among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest homology to IL-17A (sharing 55 and 40% amino acid identity to IL-17A respectively), followed by IL-17B (29%), IL-17D (25%), IL-17C (23%), and IL-17E being most distantly related to IL-17A (17%). These cytokines are all well conserved in mammals, with as much as 62–88% of amino acids conserved between the human and mouse homologs.