Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Integrin subunit alpha 2 (ITGA2) is a single pass transmembrane integrin alpha subunit encoded by ITGA2 gene. This protein localizes to plasma membrane of mesenchymal, epithelial and migratory cell populations within connective tissues. ITGA2 contains large extracellular ligand binding domains, a transmembrane helix, and a short intracellular cytoplasmic segment. ITGA2 cannot reach cell surface as a mature functional molecule without forming heterodimers with compatible beta integrin subunits. Heterodimer assembly takes place inside intracellular compartments before protein trafficking to plasma membrane. Unpaired ITGA2 subunits are retained intracellularly and are not efficiently transported to cell surface.
Once assembled into heterodimer complexes at plasma membrane, ITGA2 containing integrins establish non‑covalent molecular contacts with defined components of extracellular matrix. The intracellular cytoplasmic segment of the heterodimer provides docking sites for cytoplasmic partner proteins after extracellular molecular binding occurs. Different integrin alpha subunits possess distinct ligand binding preferences. ITGA2 containing heterodimers recognize a specific subset of extracellular matrix molecules that are not fully recognized by other integrin alpha paralogs. Variations in ITGA2 expression level may change the abundance of corresponding heterodimers at cell surface and alter the capacity for cell‑matrix molecular recognition.
Fig. 1 General domain organization and conformational architecture of an integrin α/β heterodimer, illustrating structural features applicable to ITGA2-containing integrins.1
The biological functions of ITGA2 are focused on extracellular matrix molecule recognition, integrin heterodimer formation and cell matrix interface modulation:
Creative Biolabs offers purified ITGA2 membrane samples via standardized preparation workflows, including full‑length ITGA2 constructs and isolated extracellular structural variants. Isolated extracellular fragments may not support complete heterodimer assembly and matrix binding related behaviours, while full‑length constructs may be suited for integrin subunit pairing and extracellular matrix molecular interaction related research. All samples receive routine quality screening, and functional relevant observation may only be carried out with full‑length samples under simulated membrane environments. All sample batches follow unified processing standards to maintain consistent structural features for comparative laboratory analysis across separate test groups.
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Creative Biolabs provides adjustable ITGA2 expression cell models with varied expression levels, applicable to transmembrane integrin subunit structural characteristic observation and cell matrix molecular interaction related research. Sample evaluation includes sustained target expression detection and preliminary intermolecular interaction associated observation, which can support comparative analysis of integrin associated behaviours under different expression statuses. These cell systems can be matched with diverse laboratory analysis schemes to observe changes of molecular recognition efficiency under different target expression abundances.
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Antibody reagents targeting ITGA2 are generated via mature protein preparation workflows, compatible with multiple routine laboratory detection methods for cellular localization profiling and molecular complex identification, to support systematic analysis of ITGA2 distribution and integrin associated heterodimer complexes across diverse laboratory research setups. The antibody series can cooperate with other common laboratory detection reagents to complete multi dimensional observation of target distribution inside tissue samples.
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Beyond catalog products, Creative Biolabs offers specialized custom services for ITGA2 research:
ITGA2 may serve as a transmembrane integrin alpha subunit, participating in heterodimer assembly and molecular recognition toward extracellular matrix components.
ITGA2 expression status may influence cell matrix recognition and cell adhesion profiles, serving as a major regulatory mediator of cell matrix interaction related biological processes.
No, all ITGA2 related products and services are strictly for research use only, not intended for clinical related operations. All material designs and functional tests are only optimized for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full‑length ITGA2 membrane protein, target specific recombinant antibodies and adjustable expression cell research models, supporting cell extracellular matrix interaction and cell adhesion research.
Laboratory observation schemes may include integrin associated intermolecular contact tests to analyse subunit relevant behaviours under simulated cellular environments.
