Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Integrin subunit alpha X (ITGAX, also known as CD11c) is a transmembrane integrin α subunit encoded by the ITGAX gene. ITGAX preferentially assembles with ITGB2 (CD18) to form the heterodimeric integrin αXβ2 (CR4). This receptor is prominently detected on myeloid populations including dendritic cells, macrophages and monocytes, with low expression also observed in certain lymphocyte subsets.At the cell surface, αXβ2 mediates cell adhesion and migratory behaviors via binding extracellular ligands such as fibrinogen and ICAM family molecules. Under steady-state physiological conditions, basal ITGAX expression supports low-level leukocyte anchoring. Upon inflammatory stimulation and pathogen exposure, ligand-bound αXβ2 initiates intracellular signaling cascades to facilitate myeloid cell recruitment, substrate uptake and downstream antigen processing.
As a member of the β2 integrin subfamily, αXβ2 mediates myeloid cell trafficking, opsonized substrate recognition and antigen-presenting cell maturation. Altered ITGAX expression disrupts leukocyte adhesion and tissue infiltration, triggering abnormal inflammatory responses. Embedded in plasma membranes, αXβ2 uses conserved extracellular domains to bind ligands and activate intracellular cytoskeletal signaling, adjusting migratory activity based on inflammatory stimuli. Loss of ITGAX impairs systemic innate immune surveillance, making it an important research target for integrin biology and inflammatory cell migration studies.
Fig. 1 Schematic overview of human β2 integrin family. ITGAX (αX, CD11c) assembles with ITGB2 (β2, CD18) to form heterodimer integrin αXβ2 (CR4, P150,95), which recognizes ligands including iC3b, ICAM-1 and fibrinogen to mediate myeloid cell adhesion, phagocytosis and inflammatory trafficking.1
The biological functions of ITGAX are focused on matrix ligand recognition, leukocyte migratory control and myeloid inflammatory signal regulation:
Creative Biolabs offers high-quality ITGAX proteins through optimized expression systems, including full-length integrin alpha subunit and isolated extracellular ligand-binding domain variants. These products retain native conformational characteristics and ligand-dependent adhesion biological activity, suitable for integrin heterodimer interaction assays and myeloid migration modulator screening. All ITGAX proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered ITGAX stable cell lines, including overexpression and blank control models. These cell lines are optimized for integrin subunit expression profiling and myeloid migratory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
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High-specificity recombinant antibodies targeting ITGAX are developed via advanced antibody engineering technologies, with no cross-reactivity with other integrin alpha subunits. These antibodies are validated for plasma membrane subcellular localization detection and myeloid tissue expression profiling, and can be combined with integrin beta subunit detection reagents to analyze complete heterodimer adhesion complexes in immune cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for ITGAX research:
ITGAX (CD11c) exclusively combines with ITGB2 (CD18) to form integrin αXβ2 (CR4), which mediates myeloid cell adhesion, tissue migration and pathogen phagocytosis during innate immune responses.
ITGAX acts as a critical link between extracellular matrix binding and myeloid cell tissue recruitment, governing host anti-pathogen clearance and inflammatory infiltration responses.
No, all ITGAX products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length ITGAX integrin subunits, isoform-specific detection antibodies and custom stable cell lines for myeloid trafficking research.
ITGAX proteins are validated via extracellular ligand binding functional testing.
