Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Junctional adhesion molecule 3 (JAM3), better known as JAM-C, is an immunoglobulin superfamily type I transmembrane glycoprotein. It is expressed at the intercellular junctions of endothelial and epithelial cells, where it has been shown to be involved in maintaining tight junction integrity and paracellular barrier function. JAM3 binds weakly homophilically, unlike its relatives JAM1 and JAM2 but has a major role in hetero-philic interactions. It serves as a key counter-receptor for the leukocyte β2-integrins Mac-1 (CD11b/CD18) and p150, mediating firm adhesion of neutrophils to platelets or endothelial cells during inflammatory responses. JAM3 has been discovered expressed on platelets and megakaryocytes, as well as soluble forms in serum and synovial fluid suggesting a role for JAM3 in immunity and tissue homeostasis.
Fig.1 Heterophilic JAM-integrin interactions in trans.1
These biological effects of JAM3 are linked to multiple overlapping physiological and pathological areas:
Our high-quality recombinant JAM3 membrane protein catalog supports vascular biology and inflammation research. The Ig-like extracellular domains, single-pass transmembrane topology, and glycosylation of JAM3 are important considerations for protein production and experimental design. We provide JAM3 constructs and preparations suitable for different research requirements, which may include full-length membrane-associated proteins, soluble extracellular domain (ECD) fragments, and other engineered constructs. These products can support ligand-binding studies, including research on JAM3 interactions with Mac-1, as well as antibody development and characterization and structural studies. Available formats, expression systems, glycosylation status, and functional characteristics should be determined according to the corresponding product information.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
To dissect JAM3-driven biology and assess target candidates, one needs reliable, reproducible cellular models. Our stable cell lines are used to express mouse and rat wild-type and disease-associated forms of JAM3; cell lines with modulated endogenous expression for loss-of-function studies. These systems are especially designed for use in high-throughput leukocyte adhesion assays, transmigration quantification, tight junction permeability studies and profiling of indicative inflammatory cytokines to ensure the experimental uniformity necessary to power multi-phase research projects.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
Our JAM3 high-affinity recombinant antibodies are fully characterized, optimized and validated in various applications. These antibodies, developed through advanced recombinant technologies, demonstrate superior specificity, sensitivity and batch-to-batch consistency over traditional polyclonal antibodies. JAM3 recombinant antibodies used in our validation of WB, ELISA, FCM, IF, ICC, IHC and IP allow for accurate detection and quantification of JAM3 in endothelial lysates, platelet preparations; synovial fluid; tissue sections.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
We also offer bespoke services for the extraction and purification of membrane protein and antibody discovery and development, beyond our catalog products:
No, all JAM3 products and services are for research use only (RUO) and not intended for diagnostic, therapeutic, or clinical in-vitro procedures.
We sell recombinant full-length JAM3, soluble extracellular domain (ECD) and cytoplasmic tail variants of JAM3, stable cell lines expressing JAM3 or its integrin ligands, high-quality recombinant antibodies against JAM3 antibodies as well as design comprehensive custom services.
We have mouse, and rat JAM3 reagents in our catalog. Further orthologs or engineered mutants are available upon request.
Yes. With multiple tiers, we are prepared to meet academic and industrial scale-up needs at competitive prices. Visit our enquiry portal to provide us your estimate volume and timeline, and get a customized quote.
