Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
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The LAG3 gene is located in the region of human chromosome 12p13.32 and encodes the lymphocyte activation gene 3 protein (LAG-3), which belongs to the immunoglobulin superfamily. LAG-3 is a transmembrane glycoprotein composed of an extracellular region, a transmembrane region, and an intracellular region. It is mainly expressed on the surfaces of immune cells such as activated T cells, natural killer cells, and dendritic cells. As an important immune checkpoint molecule, LAG-3 negatively regulates the proliferation, activation, and cytokine secretion of T cells by binding to its ligands (such as MHC-II molecules). It plays a crucial role in maintaining immune homeostasis and preventing autoimmune reactions. This gene has multiple single nucleotide polymorphism loci. Some functional variations can affect the protein expression level or ligand binding affinity, thereby altering the intensity of immune inhibitory signals. Moreover, changes in LAG-3 expression levels are closely related to tumor immune escape, chronic viral infections, and the occurrence and development of autoimmune diseases. Therefore, LAG-3 is regarded as one of the important targets in the field of immunotherapy. The functional study of this gene provides an important molecular basis for understanding the immune regulatory network and developing new immune intervention strategies.
Fig. 1 Lymphocyte-activation gene 3 (LAG3) consists of three regions.1
The functional spectrum of LAG3 is extremely broad, and it is still expanding continuously:
Creative Biolabs offers a series of high-quality LAG3 membrane protein products, suitable for structural and functional research. Relying on the independently developed MemDX™ recombinant membrane protein technology platform, the LAG3 protein can be produced in various expression systems, including virus-like particles (VLP) and in vitro prokaryotic expression systems. These rigorously validated protein products, such as MemDX™ recombinant human LAG3 membrane protein (in virus-like particle form) and LAG3 proteins from various eukaryotic expression systems, are applicable to applications such as ELISA, antibody production and identification, binding experiments, and functional research. These products provide reliable tools for researchers to analyze the interactions and activity mechanisms of LAG3.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Constructing reliable cell models is crucial for the study of LAG3 function. As a core immune regulatory molecule, LAG3-mediated inhibitory activity is influenced by its surface expression, ligand binding state, and intracellular signaling determinants. Several motifs within the LAG3 cytoplasmic domain, including the KIEELE, FxxL, and EP regions, have been implicated in inhibitory signaling, although the precise molecular mechanisms remain under investigation. Different expression systems or modification states of LAG3 may also influence its functional behavior. Creative Biolabs provides customized LAG3 membrane protein stable expression cell models, covering various configurations such as wild type and extracellular or intracellular mutant types. These cell models stably display the target protein on the membrane and are suitable for ligand binding affinity determination, assessment of LAG3-associated inhibitory activity, and functional comparison studies among different configurations, providing a reliable and reproducible experimental platform for exploring the activation-inhibition balance, structure-function relationships of LAG3, and its role in the immune regulatory network. Our technology supports stable membrane expression and appropriate localization of the target protein to facilitate related research.
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Creative Biolabs offers highly specific recombinant antibodies targeting LAG3, produced using advanced recombinant antibody technology. Compared to traditional polyclonal antibodies, these recombinant antibodies demonstrate superior performance in terms of specificity, sensitivity, and batch-to-batch consistency. Our LAG3 recombinant antibodies support a variety of application scenarios, including Western Blot, ELISA, flow cytometry, immunofluorescence, immunocytochemistry, immunohistochemistry, and immunoprecipitation, among others. They can be used to detect the expression differences of LAG3 in different immune cell subsets, analyze its surface distribution and internalization dynamics, and study its binding relationship with ligands or other interacting proteins. These antibodies provide reliable detection tools for the structural analysis, expression regulation research, and functional mechanism exploration of LAG3.
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In addition to the standard products, Creative Biolabs also provides professional customized services for LAG3. LAG3 has multiple mutant configurations with significant functional differences. It has specific requirements in terms of protein expression, antigen design, and functional verification. Relying on our technology platform, we can assist you in completing:
LAG3 mainly participates in the negative regulation of the activity of immune cells. It inhibits the proliferation, activation and cytokine release of T cells by binding to ligands. The function of this protein is influenced by its surface expression level, conformational state and the degree of phosphorylation of intracellular signal motifs. Different mutant configurations have differences in the efficacy of inhibiting signal transduction, making it an important model for studying the relationship between the structure and function of membrane proteins and the immune regulatory network.
LAG3 has various natural variations and different splicing subtypes. These variations can lead to changes in ligand binding affinity or changes in intracellular signal transduction efficiency. Studying the polymorphisms of LAG3 helps to understand the relationship between membrane protein structure and function, the molecular basis of differences in immune suppression signal intensity, and the mechanism of protein expression regulation.
No. All LAG3 products and services of Creative Biolabs are for research purposes only and cannot be used for any clinical diagnosis, prevention, treatment or cure of any disease.
We provide a variety of products, including recombinant LAG3 membrane protein, stable cell models expressing LAG3, high-quality recombinant LAG3 antibodies, and comprehensive customized services.
