Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Lysosomal associated membrane protein 2 (LAMP2) is a heavily glycosylated single-pass integral membrane protein encoded by the LAMP2 gene, enriched on late endosomal and lysosomal limiting membranes with multiple tissue-specific splicing isoforms. LAMP2 carries dense luminal glycan chains that form a protective barrier against luminal acid hydrolases, and interacts with endocytic adaptor proteins to mediate autophagosome-lysosome fusion and endocytic cargo sorting. Loss of intact LAMP2 glycoprotein scaffold will trigger lysosomal membrane leakage and massive accumulation of undegraded intracellular waste substrates.
LAMP2 exerts dual homeostatic functions via two core structural domains: the heavily glycosylated extracellular region shields organelle lipid bilayers from hydrolytic degradation, while the short cytoplasmic tail binds vesicle trafficking adaptors to guide autophagic and endocytic cargo into lysosomal lumens. Unlike LAMP1 with partial functional redundancy, LAMP2 is irreplaceable for autophagosome tethering; LAMP2 deletion blocks autophagy flux completely, uncoupling cellular waste clearance from lysosomal degradative capacity. This dual regulatory characteristic balances steady-state cellular turnover under physiological conditions, while LAMP2 loss-of-function mutations lead to severe multi-organ lysosomal storage lesions. LAMP2 participates in broad biological processes including autophagy circulation, lysosomal morphological maturation and inherited storage diseases. Abnormal LAMP expression directly induces toxic cargo aggregation, making LAMP2 a core research marker for lysosomal and autophagy biology.
Fig. 1 Three main autophagy pathways converge at LAMP2-positive lysosomes; autophagy exerts dual roles in early colorectal cancer cell death and late tumor proliferation & metastasis.1
The biological functions of LAMP2 are focused on lysosomal membrane shielding and autophagosome fusion mediation:
Creative Biolabs offers high-quality LAMP2 proteins through optimized heterologous expression systems, including full-length glycosylated isoforms and cytoplasmic tail truncated variants with customized glycan modification profiles. These products retain native membrane scaffold activity and autophagosome binding capacity, suitable for autophagy flux research and lysosomal disorder drug screening workflows. All LAMP2 batches undergo strict quality control to ensure consistent performance and reliable application across diverse lysosomal research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered LAMP2 stable cell lines, including overexpressing and knockdown research models. These cell lines are optimized for investigating lysosomal biogenesis mechanisms and autophagy regulatory compound potency testing. Each cell line undergoes stringent validation to ensure stable isoform expression profiles and consistent membrane protection functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting LAMP2 are developed via advanced antibody engineering technologies, with no cross-reactivity with LAMP1 homologs. These antibodies are validated for multiple applications, including lysosomal immunofluorescence localization detection, Western blot expression quantification and co-immunoprecipitation analysis of autophagosome complexes, enabling precise characterization of LAMP2 expression levels and organelle subcellular distribution under physiological and pathological conditions.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for LAMP2 research:
LAMP2 is a lysosomal scaffold regulatory protein that forms luminal glycan barriers to protect organelle membranes and mediates autophagosome-lysosome fusion, fine-tuning cellular waste clearance dynamics.
LAMP2 is indispensable for autophagy flux, and its mutation causes multi-system lysosomal storage disorders. It is a critical core research target for lysosomal and autophagy biology.
No, all LAMP2 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length glycosylated LAMP2 proteins, high-specificity recombinant antibodies, and custom stable autophagy reporter cell lines, supporting comprehensive lysosomal research projects.
LAMP2 proteins are validated by lysosomal membrane protection and autophagosome fusion functional assays to retain native waste clearance regulatory function.
