Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Galectin 3 (LGALS3) is a soluble and membrane-associated glycan-binding lectin encoded by LGALS3 gene, belonging to galectin superfamily and acting as core mediator of beta-galactoside recognition, intercellular communication and tissue matrix remodeling. LGALS3 distributes widely across epithelial, immune and stromal cell populations, carrying evolutionarily conserved carbohydrate recognition domains across species, serving as essential modulator for glycoconjugate binding, cell adhesion and inflammatory signal coordination. LGALS3-mediated glycan interaction exerts decisive effects on balancing immune cell recruitment, extracellular matrix deposition and proliferative signal transmission under physiological conditions. Furthermore, LGALS3 coordinates signaling cascades governing fibroblast activation, immune cytokine secretion and apoptotic regulation to sustain intact tissue structural homeostasis. Distinct from other galectin paralogs with divergent glycan affinity, LGALS3 holds unique non-redundant functions linking glycan signaling to fibrosis and malignant transformation, making it irreplaceable for normal tissue repair, immune balance and matrix stability.
LGALS3 executes biological functions via specific recognition of beta-galactoside moieties on cell surface and matrix glycoproteins, mediating cell-cell and cell-matrix adhesion to coordinate inflammatory cell recruitment and stromal remodeling. Its conserved carbohydrate binding pockets enable precise tuning of glycan-dependent signal cascades, maintaining equilibrium between tissue repair and excessive fibrotic deposition. LGALS3 participates in diverse biological processes including immune crosstalk, extracellular matrix remodeling, cell proliferation and apoptotic control. Aberrant LGALS3 expression disrupts immune homeostasis, accelerates matrix overaccumulation and elevates risk of fibrotic lesions and malignant disorders. Therefore, LGALS3 acts as a core research target for glycoimmunology, tissue fibrosis and tumor developmental mechanisms.
Fig. 1 Galectin-3 consists of flexible N-terminal collagen-like repeats and C-terminal carbohydrate recognition domain; N-type cross-linking and C-type linear oligomerization mediate cell surface glycan bridging and intercellular adhesion.1
The biological functions of LGALS3 are focused on carbohydrate domain-mediated glycan binding, intercellular adhesion and stromal regulatory signaling:
Creative Biolabs offers high-quality LGALS3 proteins via optimized expression systems, covering full-length LGALS3 and isolated carbohydrate recognition domain variants. These products retain native glycan-binding conformation and intrinsic lectin activity, suitable for glycoprotein interaction, immune signaling and anti-fibrotic compound screening. All LGALS3 proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered LGALS3 stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for glycan signaling, stromal fibrotic phenotype and compound response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting LGALS3 are developed with advanced antibody engineering workflows, without cross-reactivity against other galectin family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, extracellular localization detection, glycan complex interaction assessment and fibrosis research, enabling precise characterization of LGALS3 expression patterns, subcellular distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for LGALS3 research:
LGALS3 is a conserved galectin lectin that recognizes beta-galactoside glycans to mediate intercellular adhesion, immune signaling and tissue matrix remodeling.
LGALS3 serves as a central link between glycan signaling, fibrosis and immune inflammation; dysregulated expression drives progressive tissue scarring and tumor progression, establishing it as a vital research target.
No, all LGALS3 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include LGALS3 proteins, high-specificity recombinant antibodies and custom stable cell lines for glycoimmunology and fibrotic disorder research.
LGALS3 proteins undergo functional verification via glycan binding affinity assessment, carbohydrate domain conformational stability evaluation.
