Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
LDL receptor related protein 1B (LRP1B) is a very large single pass transmembrane scavenger type receptor encoded by LRP1B gene. This protein localizes to plasma membrane of several cell populations. LRP1B features an exceptionally big extracellular region built from multiple repeated ligand binding module clusters, one transmembrane helix and a sizable intracellular cytoplasmic tail. Extracellular repeated module arrays are exposed to extracellular space, while cytoplasmic tail faces cell interior and contains peptide motifs for endocytic vesicle trafficking interactions. Newly synthesized LRP1B polypeptide undergoes multi step folding within endoplasmic reticulum and Golgi compartments before delivery to plasma membrane. Due to large polypeptide size, complete folding imposes high requirement for intracellular chaperone assisted quality control systems. LRP1B exhibits distinct cell type specific expression pattern and protein abundance varies according to cellular requirement for multiligand scavenger receptor function. Incompletely folded polypeptide cannot reach cell surface and will be subjected to intracellular quality control degradation pathways. Some cell populations adjust LRP1B expression level when facing shifts in extracellular molecular composition to maintain proper ligand sensing capacity.
Multiple clusters of repeated extracellular modules enable LRP1B to establish non covalent contacts with a broad spectrum of distinct soluble extracellular target molecules. After ligand engagement at cell surface, peptide motifs on intracellular cytoplasmic tail can recruit vesicle formation machineries to drive receptor ligand complex internalization into endocytic compartments. Inside endosomes, changed luminal biochemical environment may promote dissociation between receptor and bound ligands. Receptor molecules can recycle back toward plasma membrane surface, while dissociated cargo molecules are directed toward subsequent intracellular processing routes. Other LDL receptor family paralogs share partial module architecture but cannot fully replicate the broad ligand recognition range contributed by LRP1B. Variation in LRP1B expression magnitude changes overall cellular capacity for multiligand capture and endocytic uptake. Sequence change within extracellular binding module clusters can impair recognition of subsets of target ligands, while alteration of cytoplasmic sorting motifs disrupts normal receptor recycling and endocytic trafficking behaviours. Changed receptor abundance can adjust total cellular ligand capture capacity without fully eliminating endocytic related molecular activity.
Fig. 1 Topological schematic of human LRP1B scavenger receptor. It contains four extracellular ligand‑binding module clusters, a transmembrane helix, and an intracellular tail with multiple sorting motifs supporting endocytic molecular interactions.1
The biological functions of LRP1B are focused on broad spectrum extracellular multiligand recognition, receptor ligand complex endocytosis and endosomal receptor recycling:
Creative Biolabs offers purified LRP1B membrane samples via standardized preparation workflows, including full length LRP1B constructs and isolated extracellular module cluster variants. Isolated extracellular fragments may not support complete multiligand capture and cytoplasmic sorting motif dependent trafficking related behaviours, while full length constructs may be suited for large scavenger receptor mediated multiligand recognition associated research. All samples receive routine quality screening, and functional relevant observation may only be carried out with full length samples under simulated membrane environments. All sample batches follow unified processing standards to maintain consistent structural features for comparative laboratory analysis across separate test groups.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides adjustable LRP1B expression cell models with varied expression levels, applicable to large transmembrane scavenger type receptor structural characteristic observation and multiligand recognition related research. Sample evaluation includes sustained target expression detection and preliminary intermolecular interaction associated observation, which can support comparative analysis of receptor associated behaviours under different expression statuses. These cell systems can be matched with diverse laboratory analysis schemes to observe changes of ligand recognition efficiency under different target expression abundances.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
Antibody reagents targeting LRP1B are generated via mature protein preparation workflows, compatible with multiple routine laboratory detection methods for cellular localization profiling and molecular complex identification, to support systematic analysis of LRP1B distribution and scavenger receptor ligand associated molecular complexes across diverse laboratory research setups. The antibody series can cooperate with other common laboratory detection reagents to complete multi dimensional observation of target distribution inside tissue samples.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for LRP1B research:
LRP1B may function as large transmembrane scavenger type receptor and participate in broad spectrum extracellular ligand capture together with endocytic complex trafficking and receptor recycling.
LRP1B expression status may influence multiligand capture and endocytic recycling capacity, serving as a major regulatory mediator of scavenger receptor associated biological processes.
No, all LRP1B related products and services are strictly for research use only, not intended for clinical related operations. All material designs and functional tests are only optimized for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full length LRP1B membrane protein, target specific recombinant antibodies and adjustable expression cell research models, supporting large scavenger receptor ligand binding research.
Laboratory observation schemes may include multiligand scavenger receptor binding related tests to analyse receptor associated behaviours under simulated cellular environments.
