Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Monoamine oxidase B (MAOB) is a membrane-bound enzyme mainly located on the outer mitochondrial membrane. It is expressed in both the central nervous system and peripheral tissues, with particularly high levels in 5-hydroxytryptamine neurons and astrocytes. The main function of MAOB is to catalyze the oxidation and deamination reactions of monoamine neurotransmitters (such as dopamine and phenylethylamine) and exogenous amine substances (such as MPTP), thereby regulating the intracellular levels of these substances. In terms of pathophysiology, abnormal MAOB activity is closely related to various neurological diseases such as Parkinson's disease, depression, and Alzheimer's disease. Selective inhibition of MAOB can increase the dopamine level in the brain and slow down the progression of the disease. Therefore, MAOB is considered an important drug target for treating neurodegenerative diseases such as Parkinson's disease, and its inhibitors have been widely used in clinical practice.
Fig. 1 The traditional view on MAOB as a DA- and MPTP-metabolizing enzyme.1
The functional profile of MAOB is concentrated and highly specific, mainly manifested as:
Creative Biolabs offers a series of high-quality MAOB-related products, suitable for enzyme function research and drug screening. We employ a stable recombinant protein expression technology to produce MAOB proteins from different sources, including human and mouse sources. We can provide recombinant proteins produced in various expression systems. These products, which have been verified for activity, are applicable for ELISA, inhibitor screening, antibody development, and enzyme kinetics research, providing reliable tools for exploring the role of MAOB in dopamine metabolism and Parkinson's disease.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Developing robust cellular models is critical for MAOB research. Creative Biolabs provides custom-engineered MAOB membrane protein stable cell lines that reliably express high levels of target MAOB. These stable cell lines are ideal for drug screening, ligand binding studies, functional assays, and high-throughput screening, offering a consistent and reproducible platform for investigating MAOB biology and pharmacology. Our expertise ensures optimal expression and cellular integrity, accelerating your research pipeline.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
Our comprehensive portfolio includes high-affinity recombinant antibodies targeting MAOB, developed to meet the rigorous demands of various research applications. These antibodies, produced using advanced recombinant technologies, offer superior specificity, sensitivity, and batch-to-batch consistency compared to traditional polyclonal antibodies. Our MAOB recombinant antibodies are validated for use in Western Blotting (WB), ELISA, Flow Cytometry (FCM), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC), and Immunoprecipitation (IP), empowering accurate detection and quantification of MAOB in diverse sample types.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond our catalog products, Creative Biolabs offers specialized custom services for membrane protein and antibody discovery & development. Leveraging our extensive expertise and state-of-the-art platforms, we can assist you with:
MAOB is mainly located on the outer mitochondrial membrane and is responsible for catalyzing the oxidation and deamination reactions of monoamine neurotransmitters such as dopamine, thereby regulating the neurotransmitter levels in the brain. In addition, it can also metabolize exogenous substances such as MPTP, converting them into the toxic MPP⁺.
The activity of MAOB is significantly elevated in the brains of Parkinson's disease patients, and it is closely related to oxidative stress and neuronal damage. By blocking MAOB with specific inhibitors, the level of dopamine can be effectively increased and the progression of the disease can be delayed. Therefore, it has become a key target for drug development in neurodegenerative diseases.
No, all Creative Biolabs' MAOB products and services are strictly for research use only and are not intended for clinical diagnosis, prevention, treatment, or cure of any disease.
We offer a range of products, including recombinant MAOB membrane proteins, stable cell lines expressing MAOB, and high-quality recombinant MAOB antibodies, along with comprehensive custom services.
