Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Mitofusin 2 (MFN2) is an irreplaceable mitochondrial outer membrane GTPase encoded by the MFN2 gene, belonging to the mitofusin family and acting as the central effector of mitochondrial membrane fusion, organelle network remodeling and inter-organelle communication regulation. MFN2 is widely distributed across multiple tissue cell types, with evolutionarily conserved dual transmembrane domains and catalytic GTPase domains across species, serving as an essential modulator for outer mitochondrial membrane merging, mitochondrial network integrity maintenance and endoplasmic reticulum-mitochondria tethering. MFN2-mediated membrane fusion activity exerts decisive effects on sustaining uniform mitochondrial bioenergetic function, organelle distribution and intracellular metabolite exchange under physiological conditions. Furthermore, MFN2 coordinates downstream signaling cascades governing organelle quality control, cellular calcium balance and neuronal compartment homeostasis to safeguard intact cellular physiological function. Distinct from other mitofusin paralogs with divergent tissue distribution profiles, MFN2 carries unique non-redundant duties in shaping mitochondrial architecture and stabilizing organelle cross-talk, rendering it indispensable for regular energy metabolism, peripheral neuron maintenance and overall cellular stress resistance.
MFN2 executes biological functions through binding guanosine triphosphate to trigger conformational rearrangement, driving juxtaposed outer mitochondrial membranes to merge and reconstruct interconnected mitochondrial networks, which supports balanced energy supply throughout cellular compartments. Its conserved functional domains mediate GTP hydrolysis and membrane tethering, enabling precise tuning of mitochondrial dynamics and inter-organelle signal transmission. MFN2-dependent signaling sustains systemic cellular metabolic equilibrium, covering intact mitochondrial fusion cycles, coordinated ER-mitochondria contact and persistent organelle quality surveillance. MFN2 participates in an extensive spectrum of biological processes, such as mitochondrial morphology remodeling, bioenergetic homeostasis modulation, intracellular calcium signaling and peripheral nervous system development. Aberrant expression or functional impairment of MFN2 severely disrupts mitochondrial network stability, disturbs organelle metabolite exchange and elevates susceptibility to degenerative disorders, including Charcot-Marie-Tooth type 2A neuropathy, metabolic cardiomyopathy and neurodegenerative lesions. Therefore, MFN2 constitutes a pivotal research target for investigating mitochondrial biology, organelle physiology and degenerative disease pathogenic mechanisms.
Fig. 1 MFN2 coordinates mitochondrial fusion, ER-mitochondria calcium communication and PINK/Parkin-dependent mitophagy; together with OPA1, it controls cristae remodeling, respiratory assembly and mitochondrial metabolic signaling to sustain organelle homeostasis.1
The biological functions of MFN2 are focused on GTPase-mediated mitochondrial fusion, organelle network homeostasis and inter-membrane communication:
Creative Biolabs offers high-quality MFN2 proteins via optimized expression systems, covering full-length MFN2 and isolated functional domain variants. These products retain native spatial conformation and intrinsic GTPase biological activity, suitable for mitochondrial fusion activity analysis, organelle interaction studies and small molecule compound screening targeting degenerative diseases. All MFN2 proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered MFN2 stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for mitochondrial dynamic research, organelle crosstalk observation and compound response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting MFN2 are developed with advanced antibody engineering workflows, without cross-reactivity against other mitofusin family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, mitochondrial membrane localization detection, organelle binding interaction assessment and degenerative disease research, enabling precise characterization of MFN2 expression patterns, subcellular compartment distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for MFN2 research:
MFN2 is a core mitochondrial outer membrane GTPase that mediates outer mitochondrial membrane fusion, organelle network remodeling and endoplasmic reticulum-mitochondria tethering.
MFN2 exerts irreplaceable control over mitochondrial dynamics and peripheral neuron integrity; its functional defects trigger inherited peripheral neuropathies, establishing it as a vital research target.
No, all MFN2 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include MFN2 proteins, high-specificity recombinant antibodies and custom stable cell lines for mitochondrial and degenerative disease research.
MFN2 proteins undergo functional verification via GTPase activity assessment, membrane tethering capability analysis and conformational stability evaluation.
