Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Melanoregulin (MREG) is an integral melanosome membrane protein encoded by the MREG gene, selectively expressed in melanocytic cell lineages, localized to melanosome limiting membranes and vesicle transport intermediates. Distinct from generic lysosomal membrane factors, MREG mediates melanosome tethering and transfer between melanocytes and keratinocytes via conserved membrane interaction motifs, while stabilizing melanin storage compartments to avoid premature pigment release. Under steady pigment homeostasis, basal MREG expression sustains ordered melanosome maturation and intercellular pigment delivery. Upon melanogenic stimulation, elevated MREG levels facilitate vesicular melanosome trafficking toward cell peripheral junctions for intercellular transfer. Unlike ubiquitous organelle membrane proteins, MREG carries melanocyte-restricted pigment transport functions that cannot be fully compensated by other trafficking factors, linking melanosome membrane dynamics directly to skin pigmentation pathways. Loss of functional MREG disrupts melanosome distribution and impairs pigment transfer, while altered expression drives uneven pigment deposition, establishing MREG as a core research target for melanosome membrane biology and pigmentation regulatory compound screening.
MREG executes melanosome trafficking regulatory function embedded within pigment organelle lipid bilayers, utilizing conserved membrane interaction domains to mediate melanosome anchoring and vesicle shuttling. Conserved binding motifs exclusively associate with melanocyte transport machinery, separating its functional spectrum from general endolysosomal membrane proteins. MREG-mediated organelle transport bridges intracellular melanin storage and intercellular pigment delivery, balancing melanosome maturation rate and peripheral trafficking according to melanogenic signaling intensity. MREG participates in melanosome biogenesis, keratinocyte pigment transfer and epidermal pigment gradient formation. Deficient MREG expression disrupts ordered pigment distribution. Therefore, MREG represents a pivotal research target for pigment cell membrane protein study and dermatological pigment modulator screening.
Fig. 1 Schematic of bidirectional melanosome trafficking in melanocytes, highlighting MREG-RILP-dynein complex mediating retrograde transport of mature melanosomes to perinuclear region.1
The biological functions of MREG are focused on melanosome membrane anchoring, vesicular trafficking and epidermal pigment control:
Creative Biolabs offers high-quality MREG proteins through optimized expression systems. These products retain native melanosome trafficking biological activity, suitable for organelle interaction and pigment modulator screening. All MREG proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered MREG stable cell lines, including overexpression and blank control models. These cell lines are optimized for melanosome membrane profiling and pigment trafficking functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting MREG are developed via advanced antibody engineering technologies. These antibodies are validated for melanosome membrane localization detection and melanocyte tissue expression profiling, and can be combined with melanin marker reagents to analyze complete melanosome trafficking complexes in pigment cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for MREG research:
MREG is a melanosome membrane protein that regulates organelle tethering and intercellular melanin transfer between melanocytes and keratinocytes.
MREG acts as a central coordinator of melanosome trafficking, governing epidermal pigment distribution patterns.
No, all MREG products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length MREG melanosome membrane proteins, isoform-specific detection antibodies and custom stable cell lines for pigment cell research.
MREG proteins are validated via melanosome tethering and pigment trafficking functional testing.
