Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Nucleoporin 98 and 96 precursor (NUP98) is a large nuclear pore scaffold precursor protein encoded by the NUP98 gene, translated as a single polypeptide cleaved into NUP98 and NUP96 subunits, localized to nuclear pore complex (NPC) and mitotic spindle microtubules. Distinct from smaller FG nucleoporins, NUP98 acts as a core architectural scaffold linking inner and outer NPC rings, while coordinating spindle microtubule anchoring during cell division. Under interphase conditions, mature NUP98 maintains selective nucleocytoplasmic shuttling of transcription factors and mRNA transcripts. Upon mitotic nuclear envelope breakdown, soluble NUP98 fragments associate with spindle fibers to support faithful chromosome segregation. Unlike transport-only nucleoporins, NUP98 carries dual structural and mitotic functions that cannot be fully substituted by other NPC components, linking nuclear pore assembly to cell cycle progression pathways. Loss of functional NUP98 disrupts nucleocytoplasmic transport and induces mitotic errors, while NUP98 fusion oncoproteins drive hematopoietic malignancy, establishing NUP98 as a core research target for nuclear pore biology and leukemic compound screening.
NUP98 executes multi-domain scaffold function anchored within nuclear pore superstructures, utilizing N-terminal FG repeats and C-terminal coiled-coil domains to bridge nucleoporin subcomplexes. Conserved flexible FG motifs facilitate karyopherin cargo translocation through NPC channels. NUP98-mediated scaffold assembly bridges nuclear envelope architecture and cell cycle spindle regulation, balancing nucleocytoplasmic transport throughput and mitotic fidelity according to proliferative state. NUP98 participates in mRNA export, transcription factor shuttling and metaphase chromosome alignment. Deficient NUP98 expression collapses nuclear pore architecture and impairs cell cycle progression. Therefore, NUP98 represents a pivotal research target for nucleoporin study and hematopoietic tumor screening.
Fig. 1 Schematic multi-location distribution of NUP98 within human nuclear pore complex and its interaction with RAE1 transport cofactor.1
The biological functions of NUP98 are focused on nuclear pore assembly, karyopherin transport and mitotic control:
Creative Biolabs offers high-quality NUP98 proteins through optimized expression systems, including full-length precursor and isolated FG/coiled-coil domain variants. These products retain native NPC scaffold and karyopherin binding biological activity, suitable for nuclear pore interaction and mitosis screening. All NUP98 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered NUP98 stable cell lines, including overexpression and blank control models. These cell lines are optimized for nucleoporin profiling and nuclear transport functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting NUP98 are developed via advanced antibody engineering technologies, with no cross-reactivity with other FG nucleoporins. These antibodies are validated for nuclear rim and mitotic spindle localization detection and hematopoietic tissue profiling, and can be combined with karyopherin markers to analyze complete NPC scaffold complexes in proliferative cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for NUP98 research:
NUP98 is a precursor nucleoporin cleaved into NUP98/NUP96 that forms nuclear pore scaffold and supports mitotic spindle stability.
NUP98 controls selective nuclear transport and recurrent NUP98 gene fusions drive hematopoietic malignancies.
No, all NUP98 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length NUP98 precursor proteins, isoform-specific detection antibodies and custom stable cell lines for nuclear pore research.
NUP98 proteins are validated via nucleoporin complex assembly and karyopherin binding functional testing.
