Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Structural characteristics and physiological immune function: Programmed Death Ligand 2(PDCD1LG2) is encoded by PDCD1LG2 gene, belonging to type I transmembrane immunomodulatory ligand protein, which is mainly expressed in the lipid bilayer structure of cell membrane of antigen presenting cells. The protein is significantly different from secreted soluble cytokines, and its structure contains conservative extracellular immunoglobulin-like binding domain and short cytoplasmic terminal sequence, but it does not have intracellular kinase catalytic activity structure. As a B7 family ligand molecule anchored on the cell membrane surface, PDCD1LG2 can specifically bind to the corresponding receptors on the surface of immune cells under physiological steady-state conditions. When the body lacks enough membrane-bound immune regulatory factors, T cells are prone to overactivation and immune response disorder, and PDCD1LG2 can play an effective role in immune buffer regulation and maintain the dynamic balance of lymphocyte immune activity in different lymphoid tissue microenvironment. Due to the difference of receptor-ligand composition patterns in different immune microenvironments, the multicellular immune system needs to rely on a variety of B7 family membrane ligand molecules to maintain the overall lymphocyte response steady state, in which the membrane-located PDCD1LG2 can continuously interact with the surface receptors of the target immune cells, inhibit the abnormal immune response mediated by lymphocytes, and stabilize the immune balance of local tissues.
Mutation effect, regulatory mechanism and research value: When PDCD1LG2 gene mutates, it will change the binding affinity between protein and downstream receptor, and trigger abnormal remodeling of local immune response mode. Among all transmembrane ligands in B7 family, only PDCD1LG2 has dual functions of receptor binding and in-situ immune regulation of cell membrane, and no other family member can completely replace its unique biological function. The expression abundance of PDCD1LG2 is closely related to the activation state of antigen presenting cells, which is an important research target to explore the function of B7 family membrane ligands and analyze the immune regulation mechanism of lymphocytes. On the level of molecular regulation, PDCD1LG2 is stably embedded in the lipid bilayer of cell membrane, which can participate in immune regulation by binding to the target receptor complex, and this mode of action will not induce a continuous intracellular signal cascade reaction. Compared with completely soluble immune regulatory factors, its unique transmembrane localization enables it to regulate local immune signals by cell contact and mediate reversible intercellular immune information exchange. When the function or expression level of PDCD1LG2 protein decreases, the receptor-ligand dependent lymphocyte regulation mechanism will be disordered, and the immune response buffering capacity of local tissues will be significantly weakened, further confirming the important scientific research value of PDCD1LG2 in the basic research of B7 family transmembrane ligands.
Fig. 1 Schematic gene-to-protein domain-topology diagram of human type-I transmembrane immune ligand PDCD1LG2 (PD-L2), depicting N-terminal signal peptide, extracellular IgV-like and IgC-like domains, single-pass transmembrane segment and intracellular terminal region.1
The biological functions of transmembrane PDCD1LG2 immune-regulatory ligand protein are focused on sustained cell-surface receptor engagement and lymphocyte-response coordination:
Creative Biolabs offers purified PDCD1LG2 membrane samples produced under unified preparation workflows, including full-length PDCD1LG2 constructs and isolated extracellular immunoglobulin-like domain variants. Truncated extracellular fragments cannot support complete receptor-engagement behaviours, while full-length constructs suit research focused on B7-family ligand-receptor association and cell-surface immune-modulatory observation. All batches receive uniform quality screening. Functional relevant observation may only be carried out with full-length samples under simulated membrane microenvironment setups. Consistent structural features are preserved across batches to support comparative laboratory analysis across separate test groups. Full-length PDCD1LG2 samples retain intact extracellular receptor-binding motif conformation after standardized purification, which supports reliable detection of weak and transient ligand-receptor contacts for comparative functional analysis.
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Creative Biolabs provides adjustable PDCD1LG2 expression cell research models with varied expression levels, applicable to structural observation of B7-family transmembrane ligands and research into ligand-receptor molecular interaction. Sample evaluation includes sustained target expression detection and preliminary receptor-interaction observation, enabling side-by-side comparison of ligand-binding behaviours under differing expression abundances. These cell systems can pair with diverse laboratory analysis schemes to track changes in receptor-engagement efficiency alongside shifting target protein levels.
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Anti-PDCD1LG2 recombinant antibodies are generated via standardized protein preparation workflows, compatible with routine laboratory detection techniques for plasma membrane localization mapping and identification of ligand-receptor molecular complexes. The antibody series can work alongside common laboratory detection reagents to realize multi-dimensional observation of target distribution within lymphoid-related tissue samples.
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Beyond catalog products, Creative Biolabs offers specialized custom services for PDCD1LG2 research:
PDCD1LG2 might act as a B7-family type-I transmembrane ligand and participate in cell-surface receptor engagement to modulate lymphocyte-dependent immune responses.
PDCD1LG2 expression status could alter ligand-receptor engagement efficiency and local lymphocyte-response intensity, serving as a major regulatory mediator of cell-contact-dependent immune biological processes.
No, all PDCD1LG2 related products and services are strictly for research use only, and cannot be applied in clinical workflows. All material designs and functional tests are optimized exclusively for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full-length PDCD1LG2 membrane protein, target-specific recombinant antibodies and tunable expression cell research models, supporting research on lymphoid immune homeostasis and B7-family ligand-receptor-mediated immune tuning.
Laboratory observation schemes may include ligand-receptor interaction related tests to analyze molecular-binding associated behaviors under simulated membrane environments.
