Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
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The PDGFRA gene at 4q12 encodes platelet-derived growth factor receptor alpha, a type I transmembrane glycoprotein of 1,089 amino acids belonging to the class III receptor tyrosine kinase family. PDGFRA contains five extracellular immunoglobulin-like domains, a single transmembrane helix, and a split intracellular tyrosine kinase domain with a kinase insert. The mature glycosylated protein is approximately 170 kDa and is expressed on mesenchymal cells, oligodendrocyte precursor cells, fibroblasts, and vascular smooth muscle cells. PDGFRA is activated by PDGF-AA, PDGF-BB, and PDGF-CC homodimers, which induce receptor dimerization, autophosphorylation, and activation of PI3K/AKT, MAPK/ERK, PLCγ, and STAT pathways driving cell proliferation, migration, and survival. PDGFRA signaling is essential for embryonic development including neural crest migration and organogenesis. Activating PDGFRA mutations drive gastrointestinal stromal tumors, with the D842V substitution being the most common imatinib-resistant variant. PDGFRA amplifications occur in glioblastoma, while chromosomal rearrangements such as FIP1L1-PDGFRA are found in specific myeloid and lymphoid neoplasms. PDGFRA is therefore an important target in oncology, developmental biology, and receptor tyrosine kinase research, providing tools for understanding growth factor receptor signaling and kinase-targeted therapeutics.
Fig. 1 Antibody- and Aptamer-Mediated PDGFRA Pathway Blockade.1
The functional spectrum of PDGFRA spans developmental signaling and oncogenic biology:
Creative Biolabs offers a series of high-quality PDGFRA membrane protein products, suitable for structural and functional studies of receptor tyrosine kinase signaling. Built on the independently developed MemDX™ recombinant membrane protein technology platform, PDGFRA proteins can be generated through various expression systems, including virus-like particles (VLP) and in vitro prokaryotic expression systems. These thoroughly characterized protein products, such as MemDX™ recombinant human PDGFRA membrane protein as virus-like particles and human PDGFRA proteins from diverse expression systems, can be used in ELISA, antibody screening, ligand binding assays, and kinase activity studies, providing reliable tools for analyzing the activation mechanism and downstream signaling of PDGFRA.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Constructing a robust cell model is essential for investigating PDGFRA-mediated signaling and oncogenic transformation. As a receptor tyrosine kinase that drives proliferation through PI3K/AKT and MAPK pathways, PDGFRA expression level and kinase activity directly determine downstream signaling and cellular responses. Activating mutations may lead to constitutive kinase activity and oncogenic transformation. Creative Biolabs offers customized PDGFRA membrane protein stable transfection cell models, encompassing wild-type and oncogenic variant forms including D842V. These models express the target protein on the plasma membrane, and are suitable for studies on PDGFRA kinase activation, ligand-stimulated signaling, evaluation of variant-dependent kinase activity, and drug response profiling, providing a reliable platform for exploring PDGFRA structure-function relationships, oncogenic mutations, and kinase-targeted therapeutic development. Our technology ensures cell membrane integrity and correct protein localization, facilitating your research.
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Creative Biolabs offers highly specific recombinant antibodies targeting PDGFRA, manufactured using advanced recombinant antibody technology. Compared to traditional antibodies, these recombinant antibodies deliver improved performance in specificity, sensitivity, and batch-to-batch consistency. They also support various modifications and labeling strategies. Our PDGFRA recombinant antibodies are suitable for a broad range of applications, including Western Blot, ELISA, flow cytometry, immunofluorescence, immunocytochemistry, immunohistochemistry, and immunoprecipitation, and can be used to examine PDGFRA expression levels across diverse tissues and tumor specimens, analyze its subcellular localization at the plasma membrane, and conduct related investigations such as ligand binding studies and phosphorylation analysis. These antibodies provide dependable detection reagents for the structural characterization, functional investigation of PDGFRA, and the analysis of its role in cell signaling and oncogenesis.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
In addition to the standard products, Creative Biolabs also offers professional customized services for PDGFRA. PDGFRA has oncogenic mutations with functional consequences, including the D842V variant that confers imatinib resistance and additional alterations in GIST and glioblastoma. These variants present specific requirements in protein expression, kinase activity analysis, and functional characterization. Leveraging our technology platform, we can assist you in completing the following customized projects:
PDGFRA encodes platelet-derived growth factor receptor alpha, a class III receptor tyrosine kinase activated by PDGF-AA, PDGF-BB, and PDGF-CC. Ligand binding induces receptor dimerization and autophosphorylation, activating PI3K/AKT, MAPK/ERK, and PLCγ signaling pathways that regulate cell proliferation, migration, and survival. PDGFRA is essential for embryonic development including neural crest migration and organogenesis.
Activating PDGFRA mutations drive gastrointestinal stromal tumors, with the D842V variant conferring imatinib resistance and targeted by the selective inhibitor avapritinib. PDGFRA amplification occurs in glioblastoma, and chromosomal translocations generate oncogenic PDGFRA fusions in dermatofibrosarcoma protuberans. PDGFRA is therefore a clinically validated target in precision oncology and kinase biology.
Not applicable. All PDGFRA products and services provided by Creative Biolabs are for research purposes only and cannot be used for any clinical diagnosis, prevention, treatment or cure of any disease.
We offer a variety of product types, including recombinant PDGFRA membrane proteins, stable cell models expressing PDGFRA, high-quality recombinant PDGFRA antibodies, as well as comprehensive customized services.
