Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Polymeric immunoglobulin receptor (pIgR) is an epithelium-specific transmembrane transport receptor encoded by the PIGR gene, belonging to immunoglobulin superfamily and acting as the exclusive effector of polymeric immunoglobulin transcytosis across mucosal epithelial barriers. pIgR is selectively expressed within mucosal epithelial cell layers of respiratory, intestinal and glandular tissues, with evolutionarily conserved immunoglobulin-binding ectodomains and cytoplasmic signaling segments across species, serving as an essential modulator for dimeric IgA and pentameric IgM internalization, intracellular vesicular transport and secretory antibody release onto mucosal surfaces. pIgR-mediated transcytosis activity exerts decisive effects on sustaining abundant secretory antibody coating at mucosal barriers, limiting pathogen invasion across epithelial layers and maintaining localized mucosal immune defense under physiological conditions. Furthermore, pIgR coordinates downstream signaling cascades governing epithelial barrier integrity, inflammatory cytokine regulation and commensal microbe immune tolerance to safeguard intact mucosal tissue homeostasis. Distinct from other immunoglobulin-binding receptors with divergent ligand affinity profiles, pIgR carries unique non-redundant duties in polarized polymeric antibody translocation across epithelial monolayers, rendering it indispensable for regular mucosal barrier immunity, secretory antibody generation and overall tissue pathogen resistance.
pIgR executes biological functions through binding polymeric immunoglobulin ligands at basolateral epithelial surfaces to trigger endocytic vesicle formation, driving directional intracellular transport toward apical epithelial membranes for proteolytic cleavage and release of secretory antibody complexes into mucosal lumens, which establishes continuous antibody-mediated immune protection at body barrier surfaces. Its conserved extracellular ligand-binding domains mediate specific polymeric Ig recognition and vesicle trafficking coordination, enabling precise tuning of secretory antibody output and mucosal barrier immune signal transmission. pIgR-dependent signaling sustains systemic mucosal immune equilibrium, covering intact polymeric Ig transcytosis cycles, coordinated epithelial barrier stability and persistent luminal pathogen surveillance. pIgR participates in an extensive spectrum of biological processes, such as polymeric immunoglobulin transport, secretory antibody biogenesis, mucosal epithelial barrier maintenance and commensal immune tolerance regulation. Aberrant expression or functional deficiency of pIgR severely reduces luminal secretory antibody concentration, disturbs epithelial pathogen defense and elevates susceptibility to mucosal infectious and inflammatory disorders, including enteric microbial infection and chronic mucosal inflammatory lesions. Therefore, pIgR constitutes a pivotal research target for investigating mucosal immunology, epithelial transport physiology and infectious barrier disease pathogenic mechanisms.
Fig. 1 Biogenesis of J-chain-containing pentameric IgM and dimeric IgA in plasma cells, followed by the full pIgR-mediated transcytosis cycle across epithelial cells: basolateral binding, endocytosis, endosomal sorting, and apical proteolytic cleavage to release SC-associated secretory immunoglobulins into mucosal lumen.1
The biological functions of pIgR are focused on epithelial ligand binding, vesicular polymeric immunoglobulin transport and mucosal secretory antibody generation:
Creative Biolabs offers high-quality pIgR proteins via optimized expression systems, covering full-length pIgR and isolated ligand-binding ectodomain variants. These products retain native spatial conformation and intrinsic immunoglobulin-binding biological activity, suitable for receptor-ligand interaction analysis, mucosal transport pathway studies and small molecule compound screening targeting mucosal infectious disorders. All pIgR proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered pIgR stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for mucosal transport research, secretory antibody secretion phenotype observation and compound barrier-protective response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting pIgR are developed with advanced antibody engineering workflows, without cross-reactivity against other immunoglobulin receptor family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, epithelial membrane localization detection, receptor-ligand binding interaction assessment and mucosal immunity research, enabling precise characterization of pIgR expression patterns, subcellular compartment distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for pIgR research:
pIgR is a core mucosal epithelial receptor that mediates basolateral polymeric immunoglobulin uptake, vesicular transcytosis and luminal secretory antibody release.
pIgR exerts irreplaceable control over mucosal barrier secretory immunity; its functional deficiency weakens epithelial pathogen defense, establishing it as a vital research target.
No, all pIgR products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include pIgR proteins, high-specificity recombinant antibodies and custom stable cell lines for mucosal barrier immunology research.
pIgR proteins undergo functional verification via polymeric immunoglobulin ligand binding assessment, receptor conformational analysis and binding stability evaluation.
