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Plau

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell
migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's
disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by
specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to
form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the
catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular
weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into
a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the
uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2009)

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