Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Parathyroid hormone 1 receptor (PTH1R) is a class B seven-transmembrane G protein-coupled receptor encoded by the PTH1R gene, predominantly expressed in osteoblasts, renal tubular epithelium and chondrocyte populations, localized exclusively to plasma membrane lipid bilayers. Distinct from other peptide GPCR paralogs, PTH1R specifically binds endocrine PTH and paracrine PTHrP ligands to simultaneously activate Gs-cAMP and Gq-IP3-calcium dual signaling cascades. Under physiological steady-state mineral balance, basal PTH1R expression maintains mild bone turnover and renal calcium reabsorption without abnormal serum calcium fluctuation. Upon hypocalcemic stimulation, elevated circulating PTH engages cell-surface PTH1R to amplify osteoclastogenic signals and boost tubular calcium retention programs. Unlike tissue-restricted peptide receptors, PTH1R carries systemic calcium-regulating functions that cannot be fully substituted by other GPCR members, linking hormone ligand recognition to skeletal mineral homeostasis pathways. Loss of functional PTH1R disrupts calcium reabsorption and impairs bone remodeling capacity, while sustained receptor hyperactivation induces pathological hypercalcemia and bone loss, establishing PTH1R as a core research target for class B GPCR biology and anti-osteoporotic compound screening.
PTH1R executes dual G-protein dependent signal transduction function embedded within osteoblastic and renal cell membranes, utilizing conserved extracellular ligand-binding ectodomains to selectively capture PTH/PTHrP polypeptide ligands. Conserved ligand-binding pocket architecture distinguishes its peptide selectivity from unrelated hormone receptors. PTH1R-mediated conformational rearrangement bridges extracellular hormone stimulation and dual intracellular secondary messenger cascades, balancing bone resorption and renal calcium transport magnitude according to circulating mineral hormone levels. PTH1R participates in embryonic skeletal development, adult bone turnover and systemic calcium-phosphate homeostasis. Deficient PTH1R signaling leads to hypocalcemia and chondrodysplasia phenotypes. Therefore, PTH1R represents a pivotal research target for peptide GPCR study and metabolic bone compound screening.
Fig. 1 Dual intracrine and paracrine/autocrine PTHLH-PTH1R signaling axis driving neuroblastoma malignancy, with supporting quantitative data of cell invasion and senescence upon PTH1R knockdown and PTHLH ligand stimulation.1
The biological functions of PTH1R are focused on PTH/PTHrP binding, dual Gs/Gq signal initiation and calcium balance control:
Creative Biolabs offers high-quality PTH1R proteins through optimized expression systems, including full-length seven-transmembrane receptor and isolated extracellular ligand-binding domain variants. These products retain native PTH binding and dual G-protein signaling biological activity, suitable for ligand-receptor interaction assays and bone metabolic modulator screening. All PTH1R proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered PTH1R stable cell lines, including overexpression and blank control models. These cell lines are optimized for class B GPCR expression profiling and dual cAMP/calcium signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting PTH1R are developed via advanced antibody engineering technologies, with no cross-reactivity with other class B peptide GPCRs. These antibodies are validated for osteoblast/renal cell plasma membrane localization detection and skeletal tissue expression profiling, and can be combined with PTH detection reagents to analyze complete hormone-receptor signaling complexes in bone cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for PTH1R research:
PTH1R is a dual Gs/Gq-coupled class B GPCR that binds PTH and PTHrP to activate cAMP and calcium signals governing systemic calcium balance and bone remodeling.
PTH1R acts as the central endocrine receptor coordinating renal calcium reabsorption and osteoclast differentiation, representing a core target for metabolic bone disorder study.
No, all PTH1R products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length PTH1R GPCR proteins, isoform-specific detection antibodies and custom stable cell lines for skeletal calcium research.
PTH1R proteins are validated via PTH ligand binding and dual cAMP/calcium signaling functional testing.
