Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Protein tyrosine phosphatase non-receptor type 1 (PTPN1, PTP1B) is a cytoplasmic phosphatase encoded by the PTPN1 gene, highly expressed in hepatic and adipocyte populations, localized to cytoplasmic and ER-adjacent compartments. Distinct from receptor-linked phosphatase paralogs, PTPN1 dephosphorylates tyrosine residues on insulin receptor and downstream signaling intermediates to terminate insulin-dependent metabolic cascades. Under basal metabolic status, moderate PTPN1 activity maintains balanced insulin sensitivity without severe glucose dysregulation. Upon nutrient overload, elevated PTPN1 expression enhances receptor dephosphorylation to blunt glucose uptake and glycogen synthesis signals. Unlike ubiquitous housekeeping phosphatases, PTPN1 bears insulin pathway-specific inhibitory functions that cannot be fully compensated by other cytoplasmic PTP family members, linking tyrosine dephosphorylation directly to glucose metabolic pathways. Loss of functional PTPN1 amplifies insulin responsiveness and improves systemic glucose clearance, while sustained phosphatase activity drives insulin resistance, establishing PTPN1 as a core research target for metabolic phosphatase biology and anti-diabetic compound screening.
PTPN1 executes cytoplasmic tyrosine dephosphorylation function, utilizing conserved catalytic phosphatase pockets to remove phosphate groups from insulin receptor substrates. Conserved substrate recognition sequences exclusively target insulin signaling intermediates, separating its substrate spectrum from growth factor unrelated phosphatase targets. PTPN1-mediated signal termination bridges insulin receptor activation and metabolic effector suppression, balancing peripheral glucose uptake according to circulating insulin concentration. PTPN1 participates in hepatic gluconeogenesis control, adipocyte glucose handling and systemic insulin sensitivity regulation. Deficient PTPN1 expression preserves sustained insulin signal transduction and improves metabolic homeostasis. Therefore, PTPN represents a pivotal research target for metabolic phosphatase study and insulin-sensitizing compound screening.
Fig. 1 CircMAP3K4/miR-6795-5p axis upregulates PTPN1 to suppress IRS1/PI3K/Akt glucose uptake signaling and drive insulin resistance, accompanied by qPCR and western blot quantification of PTPN1 expression.1
The biological functions of PTPN1 are focused on tyrosine phosphate removal, insulin signal attenuation and glucose balance control:
Creative Biolabs offers high-quality PTPN1 proteins through optimized expression systems, including full-length cytoplasmic phosphatase and isolated catalytic domain variants. These products retain native tyrosine dephosphorylation biological activity, suitable for insulin substrate interaction assays and insulin-sensitizing modulator screening. All PTPN1 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered PTPN1 stable cell lines, including overexpression and blank control models. These cell lines are optimized for cytoplasmic phosphatase profiling and insulin signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting PTPN1 are developed via advanced antibody engineering technologies. These antibodies are validated for cytoplasmic compartment localization detection and hepatic/adipose tissue expression profiling, and can be combined with insulin receptor detection reagents to analyze complete PTPN1-substrate complexes in metabolic cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for PTPN1 research:
PTPN1 is a cytoplasmic tyrosine phosphatase that dephosphorylates insulin receptor substrates to terminate insulin metabolic signaling.
PTPN1 acts as a major negative regulator of insulin response, governing peripheral glucose homeostasis and insulin resistance development.
No, all PTPN1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length PTPN1 phosphatase proteins, isoform-specific detection antibodies and custom stable cell lines for metabolic research.
PTPN1 proteins are validated via insulin substrate dephosphorylation functional testing.
