Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
The RHCE gene encodes one of the core proteins of the Rh blood group system. RhCE is a non-glycosylated polypeptide with a molecular weight of approximately 45–50 kDa localized to the erythrocyte membrane. This protein forms a complex with the RhAG protein, jointly contributing to the structural organization of the Rh blood group complex and the integrity of the red blood cell membrane. Allelic variations of the RHCE gene directly determine the expression of the C, c, E, and e antigens. Their absence or alteration can contribute to Rh deficiency phenotypes associated with hemolytic anemia and abnormal red blood cell morphology. In clinical transfusion medicine, RHCE genotyping is of great significance for preventing hemolytic disease of the fetus and newborn and hemolytic transfusion reactions. Moreover, altered expression of Rh blood group antigens has been investigated in immune-mediated hemolytic conditions, making RHCE an important target in blood group immunology and transfusion safety research.
Fig. 1 RHCE gene changes alter RhCE protein amino acids on red cell membrane.1
The functionality spectrum of RHCE is relatively clear and mainly includes:
Creative Biolabs offers a series of high-quality RHCE membrane protein products, suitable for blood type research and antibody development. The company's unique Magic™ recombinant membrane protein technology enables the production of RHCE proteins in various expression systems, including virus-like particles (VLPs) and the in vitro expression system of E. coli. These rigorously validated proteins, such as MemDX™ recombinant human RHCE membrane protein (in VLP form) and human/mouse RHCE products expressed in HEK293 or E. coli systems, can be used for ELISA, antibody screening and identification, binding experiments, and functional studies. They provide reliable tools for researchers to analyze RHCE antigen epitopes and membrane protein functions.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Developing robust cellular models is critical for RHCE research. Creative Biolabs provides custom-engineered RHCE membrane protein stable cell lines that reliably express high levels of target RHCE. These stable cell lines are ideal for drug screening, ligand binding studies, functional assays, and high-throughput screening, offering a consistent and reproducible platform for investigating RHCE biology and pharmacology. Our expertise ensures optimal expression and cellular integrity, accelerating your research pipeline.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
Our comprehensive portfolio includes high-affinity recombinant antibodies targeting RHCE, developed to meet the rigorous demands of various research applications. These antibodies, produced using advanced recombinant technologies, offer superior specificity, sensitivity, and batch-to-batch consistency compared to traditional polyclonal antibodies. Our RHCE recombinant antibodies are validated for use in Western Blotting (WB), ELISA, Flow Cytometry (FCM), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC), and Immunoprecipitation (IP), empowering accurate detection and quantification of RHCE in diverse sample types.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond our catalog products, Creative Biolabs offers specialized custom services for membrane protein and antibody discovery & development. Leveraging our extensive expertise and state-of-the-art platforms, we can assist you with:
The RHCE gene mainly encodes the RhCE protein on the red blood cell membrane, determining the expression of the C, c, E, and e blood type antigens, and also participating in maintaining the stability of the red blood cell membrane skeleton and the transmembrane transport of ammonium ions.
The polymorphism of the RHCE gene is one of the main causes of neonatal hemolytic disease and hemolytic transfusion reactions. Accurate RHCE gene typing is of great significance for ensuring the safety of clinical blood transfusion and preventing alloimmune reactions.
No, all Creative Biolabs' RHCE products and services are strictly for research use only and are not intended for clinical diagnosis, prevention, treatment, or cure of any disease.
We offer a range of products, including recombinant RHCE membrane proteins, stable cell lines expressing RHCE, and high-quality recombinant RHCE antibodies, along with comprehensive custom services.
