Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Sodium voltage-gated channel alpha subunit 4 (SCN4A) is an indispensable skeletal muscle-specific voltage-gated sodium channel encoded by the SCN4A gene, belonging to voltage-gated sodium channel superfamily and acting as the core effector of skeletal muscle action potential initiation and sarcolemmal electrical excitability. SCN4A is selectively enriched in skeletal muscle sarcolemma membranes, carrying evolutionarily conserved four-transmembrane-domain architecture and voltage-sensing modules across species, serving as an essential modulator for rapid sodium influx upon membrane depolarization and muscle contractile signal propagation. SCN4A-mediated sodium permeation exerts decisive effects on triggering muscle electrical signals and coordinating synchronous fiber contraction under physiological conditions. Furthermore, SCN4A coordinates downstream ion balance cascades governing muscle fiber homeostasis and sarcolemmal signal stability to sustain intact neuromuscular transmission. Distinct from neuronal sodium channel paralogs with tissue-restricted expression, SCN4A carries unique non-redundant functions in skeletal muscle electrogenesis, rendering it irreplaceable for normal muscle contraction and neuromuscular signal transmission.
SCN4A executes biological functions via conformational rearrangement triggered by membrane potential shifts, opening intramembrane sodium pores to drive rapid cation inward flux and generate regenerative muscle action potentials for long-distance contractile signal delivery. Its conserved voltage-sensing and pore-forming domains enable precise tuning of muscle firing threshold and electrical signal kinetics, maintaining balanced sarcolemmal excitability. SCN4A participates in an extensive spectrum of biological processes, including muscle action potential generation, sarcolemmal ion homeostasis, neuromuscular junction signal relay and skeletal fiber maturation. Mutations or dysfunction of SCN4A severely disrupt muscle electrical excitability, impair contractile signaling and raise susceptibility to hereditary myopathic disorders, including periodic paralysis and myotonia syndromes. Therefore, SCN4A constitutes a pivotal research target for skeletal muscle electrophysiology and hereditary neuromuscular disease mechanisms.
Fig. 1 Linear topological architecture of human Nav1.4 (SCN4A) channel with four homologous domains (DI–DIV); mapped disease-causing mutation hotspots for hypokalemic periodic paralysis, congenital myopathy and myotonia, plus binding interfaces for Navβ1, ankyrin, calmodulin and syntrophin. Panel B displays positively charged arginine residues within S4 voltage-sensing helices across all four domains.1
The biological functions of SCN4A are focused on voltage-sensing domain gating and sarcolemmal sodium permeation to drive muscle electrical signaling:
Creative Biolabs offers high-quality SCN4A proteins via optimized expression systems, covering full-length SCN4A and isolated voltage-sensing domain variants. These products are suitable for sarcolemmal electrophysiology, ion channel interaction and myopathy-targeted small molecule screening. All SCN4A proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered SCN4A stable cell lines, including overexpression and gene silencing models. These cell lines are optimized for skeletal ion channel electrophysiology and myopathy phenotype research. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
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High-specificity recombinant antibodies targeting SCN4A are developed with advanced antibody engineering workflows, without cross-reactivity against other voltage-gated sodium channel isoforms. These antibodies receive multi-scenario functional validation, applicable to muscle membrane localization, channel expression profiling and ion channel interaction assessment, enabling precise characterization of SCN4A expression patterns under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for SCN4A research:
SCN4A is a skeletal muscle voltage-gated sodium channel that mediates sarcolemmal sodium influx to generate muscle action potentials and sustain neuromuscular excitability.
SCN4A is the sole major sodium channel of skeletal muscle; its pathogenic variants alter fiber excitability and cause hereditary myopathies, establishing it as a vital research target.
No, all SCN4A products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include SCN4A proteins, high-specificity recombinant antibodies and custom stable cell lines for skeletal ion channel and myopathy research.
SCN4A proteins undergo functional verification via sodium conductance and voltage gating capacity evaluation.
