Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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Solute carrier family 34 member 2(SLC34A2, also known as NaPi2b) is a multi-transmembrane apical membrane sodium-phosphate co-transporter encoded by SLC34A2 gene, which is specifically enriched in alveolar type II epithelial cells, ovarian surface epithelial cells and thyroid follicular cells, mainly located in the apical microstructure domain of cell membrane, and plays an epithelial-specific ion transport function. Different from SLC34A1 and SLC34A3 family subtypes which are specifically expressed in kidney, SLC34A2 dominates the uptake of inorganic phosphate by epithelial cells, maintains the intracellular phosphorus reserve, and provides key substrate support for basic life activities such as cell lipid synthesis and nucleic acid metabolism. Under the normal physiological state of lung, moderate SLC34A2 transport activity can stabilize the synthesis of pulmonary surfactant and ensure the normal renewal of alveolar epithelial cells and the steady state of lung tissue. After malignant transformation of cells, lung adenocarcinoma and ovarian cancer cells will significantly up-regulate the expression of SLC34A2 membrane, making this transporter a specific landmark antigen of tumor cell membrane, which can be used to mediate the precise targeted delivery of antibody drug conjugates. At the same time, the fusion of SLC34A2-ROS1 gene can activate the persistent abnormal oncogene kinase signal and drive the malignant proliferation of tumor. Other solute carrier family proteins can't compensate for the epithelial-specific phosphate transport function of SLC34A2. The loss of SLC34A2 will destroy the homeostasis of pulmonary surfactant and damage the physiological function of lung epithelium. ADC drugs targeting SLC34A2 can play a powerful anti-tumor activity, which is an irreplaceable core target for the study of phosphate transport enzymology and the screening of targeted drugs for epithelial solid tumors.
SLC34A2 is anchored in the lipid bilayer at the top of epithelial cell membrane, and plays the core role of sodium-phosphate synergistic transport by relying on sodium gradient potential energy. Through the conserved transmembrane ion coordination domain, SLC34A2 simultaneously mediates the transmembrane transport of sodium ions and inorganic phosphates, and regulates the cell phosphorus metabolism homeostasis. The specific expression characteristics of lung and ovary tissue form a clear functional differentiation with kidney phosphate transporter, and construct a dedicated phosphorus nutrition supply pathway for epithelial tissue. The ion transport process mediated by SLC34A2 can closely relate the extracellular phosphate supply level to the proliferation and metabolism of tumor cells, and dynamically balance the physiological demand for surfactant synthesis of normal epithelial cells and the metabolic consumption of malignant proliferation of tumor cells. This molecule is widely involved in the production of pulmonary surfactant, the maintenance of ovarian epithelial homeostasis and the occurrence and development of ROS1 fusion lung cancer. The defect of SLC34A2 transport function will reduce the activity of alveolar cells, limit the phosphate uptake of tumor cells and inhibit the abnormal metabolic proliferation of tumors. To sum up, SLC34A2 is the key target for the functional mechanism research of solute carrier and the development of ADC drugs targeting lung cancer.
Fig. 1 Graphical Abstract Schematic of human preimplantation embryonic progression and SLC34A2 (NaPi2b) as specific surface marker enriching transient DUX4-positive 8-cell-like iBM subpopulations from primed human embryonic stem cells.1
The biological functions of multi-transmembrane SLC34A2 symporter are fully focused on sodium-phosphate co-transport and tumor antigen presentation:
Creative Biolabs offers high-quality SLC34A2 proteins through optimized alveolar epithelial expression systems, including full-length multi-pass symporter and isolated extracellular antigen domain variants. These products retain native phosphate transport and antibody binding activity, suitable for phosphate metabolism and ADC ligand screening assays. All SLC34A2 proteins undergo strict quality control to ensure consistent performance and reliable application across pulmonary oncology research platforms.
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Creative Biolabs provides custom-engineered SLC34A2 stable cell lines, including lung tumor overexpression and blank empty vector control models. These cell lines are optimized for solute carrier profiling and ADC binding functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles during long-term tumor cell culture, and can be widely deployed for targeted antibody drug screening experiments.
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High-specificity recombinant antibodies targeting SLC34A2 are developed via advanced antibody engineering technologies, with no cross-reactivity with renal SLC34 paralogs. These antibodies are validated for alveolar and tumor apical membrane localization detection and lung tissue expression profiling, and can be combined with surfactant marker reagents to analyze complete SLC34A2 transporter complexes in lung cell models.
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Beyond catalog products, Creative Biolabs offers specialized custom services for SLC34A2 research:
A1: SLC34A2 (NaPi2b) is an apical sodium-phosphate co-transporter and specific surface biomarker for lung adenocarcinoma ADC therapy.
A2: SLC34A2 is selectively overexpressed on lung cancer cells, the leading clinical target for antibody-drug conjugates.
A3: No, all SLC34A2 products and services are strictly for research use only, not intended for clinical diagnosis or human therapeutic trials.
A4: Offerings include full-length SLC34A2 transporters, isoform-specific detection antibodies and custom stable cell lines for lung tumor research.
A5: SLC34A2 proteins are validated via sodium-phosphate co-transport and antibody binding functional testing.
