Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Solute carrier family 40 member 1 (SLC40A1) is a multi-pass membrane iron efflux transporter encoded by the SLC40A1 gene, composed of 12 transmembrane helices and cytoplasmic iron regulatory motif, acting as core export subunit for cellular ferrous iron transport complexes. SLC40A1 is highly expressed in reticuloendothelial macrophages, hepatocytes and intestinal epithelial cell populations, serving as membrane scaffold assembling iron efflux oligomers and recruiting metal-sensing kinases upon intracellular iron accumulation stimulation.
SLC40A1 fulfills physiological functions via membrane oligomerized transporter assembly, a mechanism stabilizing transmembrane ferrous iron gradients and tuning intracellular metal metabolic cascade efficiency. Unlike auxiliary iron-binding proteins, SLC40A1 cannot sustain complete iron efflux flux without intact oligomeric conformation and requires full membrane complex assembly to generate complete metabolic signal output; it recruits cytoplasmic signal mediators to transporter assemblies, separating intracellular iron storage sensing from systemic metal homeostatic transcription factor activation and maintaining steady tissue iron regulatory signals. This dual regulatory mode modulates cellular iron efflux responses triggered by metal overload, fine-tunes systemic iron circulation and metal mediator secretion levels, while sustained defective SLC40A1 efflux capacity induces intracellular iron overload and oxidative tissue lesions. SLC40A1 participates in key physiological and pathological processes including macrophage iron recycling, intestinal iron absorption control, hepatic metal storage and chronic iron overload metabolic disorders. Altered SLC40A1 expression or iron transport capacity disrupts whole-body iron equilibrium and exacerbates oxidative tissue damage, establishing SLC40A1 as a critical research target for SLC metal transporter signaling, systemic iron metabolism and iron overload disease research.
Fig. 1 SLC40A1 (FPN1)-mediated iron efflux in macrophages, duodenal epithelium and hepatocytes for systemic iron circulation.1
The biological functions of SLC40A1 are focused on SLC metal transporter oligomerization, iron efflux signal propagation and whole-body tissue metal balance:
Creative Biolabs offers high-purity SLC40A1 proteins via optimized heterologous expression platforms, including full-length transporters and isolated cytoplasmic regulatory domain variants with modified glycosylation features. These products retain native membrane folding, suitable for cellular metal transport research, transporter complex interaction detection and small molecule iron balance regulator screening. All SLC40A1 proteins undergo strict quality assessment covering purity analysis and iron efflux functional validation to preserve intact biological activity.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom SLC40A1 stable cell models with overexpression and knockdown phenotypes in macrophage, hepatic and intestinal epithelial cell backgrounds. These cell lines are optimized for research on iron efflux oligomer assembly, systemic metal homeostatic signal cascades and iron balance regulatory compound responsiveness. Each cell model receives full validation of stable expression and complete metal transport functionality.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting SLC40A1 are generated through advanced antibody engineering workflows, without cross-reactivity against other SLC metal transporter subunits. These reagents are validated for immunofluorescence macrophage membrane localization, Western blot expression profiling and co-immunoprecipitation of iron efflux oligomeric complexes, enabling precise analysis of SLC40A1 expression, subcellular localization and metal transport functional regulation.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for SLC40A1 research:
SLC40A1 is a macrophage iron efflux transporter forming homo-oligomeric membrane complexes to control cellular ferrous iron export magnitude, balance systemic iron recycling dynamics and mitigate metal overload oxidative stress upon intracellular iron accumulation.
SLC40A1 is the primary transporter mediating reticuloendothelial iron recycling; its loss of function causes progressive tissue iron overload and oxidative injury, making it an indispensable research target for metal transporter and iron metabolic disease studies.
No, all SLC40A1 products and auxiliary services are designed exclusively for laboratory research, not authorized for clinical diagnosis or therapeutic intervention.
The product portfolio includes full-length and regulatory domain-truncated SLC40A1 proteins, specific recombinant antibodies, and custom stable macrophage cell lines supporting cellular iron transport and metal metabolism research.
SLC40A1 proteins pass homo-oligomer transporter binding tests and cellular iron efflux functional verification to maintain native metal homeostatic regulatory activity in metabolic research.
