Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Syntaxin 2 (STX2) is a plasma membrane-localized SNARE protein encoded by STX2 gene, predominantly expressed in epithelial and secretory cell lineages, anchored to cell surface lipid bilayers. Distinct from Golgi-resident syntaxin paralogs, STX2 possesses cytoplasmic coiled-coil SNARE domains that selectively pair with post-Golgi secretory vesicle SNARE subunits to drive vesicle-plasma membrane fusion for cargo exocytosis. Under resting epithelial status, basal STX expression maintains low constitutive secretion without uncontrolled vesicle release. Upon mucosal stimulation or secretory demand elevation, STX2 assembles functional four-helix SNARE complexes to facilitate release of protective mucosal cargo and inflammatory mediators. Unlike intracellular trafficking syntaxins, STX2 carries plasma membrane-specific exocytosis functions that cannot be fully replaced by other syntaxin isoforms, linking post-Golgi vesicle docking to extracellular cargo secretion pathways. Loss of functional STX2 blocks epithelial exocytosis and impairs mucosal barrier protective cargo release, while overactive SNARE assembly leads to excessive secretory discharge, establishing STX2 as a core research target for plasma membrane SNARE biology and epithelial secretory modulator screening.
STX2 executes target membrane SNARE function embedded within epithelial cell surface bilayers, utilizing conserved helical coiled-coil motifs to mediate high-affinity interaction with secretory vesicle SNARE partners. Conserved binding regions restrict complex formation to post-Golgi transport vesicles, separating its trafficking spectrum from early secretory syntaxins. STX2-mediated SNARE heteromerization bridges vesicle cargo loading and extracellular exocytic release, balancing secretion intensity according to epithelial stimulus levels. STX2 participates in mucosal barrier secretion, inflammatory mediator release and epithelial cell membrane lipid turnover. Deficient STX2 expression disrupts post-Golgi vesicle fusion and weakens epithelial barrier defense capacity. Therefore, STX2 represents a pivotal research target for plasma membrane SNARE study and mucosal compound screening.
Fig. 1 Schematic of two-phase mucin granule exocytosis controlled by TSPAN8-mediated STX2 inhibition in wild-type and TSPAN8-knockout airway epithelial cells.1
The biological functions of STX2 are focused on post-Golgi vesicle SNARE assembly, plasma membrane fusion and mucosal secretory control:
Creative Biolabs offers high-quality STX2 proteins through optimized expression systems, including full-length plasma membrane syntaxin and isolated coiled-coil SNARE domain variants. These products retain native SNARE heteromerization activity, suitable for vesicle-membrane interaction and epithelial secretion modulator screening. All STX2 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered STX2 stable cell lines, including overexpression and blank control models. These cell lines are optimized for plasma membrane SNARE expression profiling and exocytosis functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting STX2 are developed via advanced antibody engineering technologies. These antibodies are validated for epithelial plasma membrane localization detection and mucosal tissue expression profiling, and can be combined with secretory vesicle marker reagents to analyze complete exocytic SNARE complexes in epithelial cell models.
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Beyond catalog products, Creative Biolabs offers specialized custom services for STX2 research:
STX2 is a plasma membrane syntaxin that forms SNARE complexes with secretory vesicles to mediate epithelial cargo exocytosis.
STX2 links post-Golgi vesicle trafficking to mucosal barrier secretion, governing epithelial protective mediator release.
No, all STX2 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length STX2 syntaxins, isoform-specific detection antibodies and custom stable cell lines for epithelial secretion research.
STX2 proteins are validated via secretory vesicle SNARE binding functional testing.
