Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Syntaxin 3 (STX3) is an integral plasma membrane SNARE protein encoded by STX3 gene, selectively enriched on apical epithelial membrane domains, localized to apical lipid bilayers and transport vesicle intermediates. Distinct from basolateral syntaxin paralogs, STX3 forms target SNARE complexes with apical vesicle V-SNAREs to mediate polarized exocytosis of luminal cargo. Under resting epithelial homeostasis, basal STX3 expression sustains ordered apical secretion without cargo mis-sorting to basolateral surfaces. Upon secretory stimulation, elevated STX3 complex assembly accelerates apical vesicle docking and fusion to release mucins, enzymes and surface receptors. Unlike ubiquitously expressed syntaxins, STX3 bears apical polarity-specific trafficking functions that cannot be fully compensated by other syntaxin family members, linking polarized SNARE assembly to epithelial barrier pathways. Loss of functional STX3 disrupts apical cargo sorting and impairs mucosal barrier integrity, while overexpression accelerates unregulated apical exocytosis, establishing STX3 as a core research target for epithelial SNARE biology and mucosal compound screening.
STX3 executes target membrane SNARE function embedded within apical epithelial bilayers, utilizing conserved coiled-coil helices to selectively pair with vesicular SNARE subunits carried on apical transport carriers. Conserved interaction regions restrict binding to apical V-SNAREs, separating its polarity-specific function from basolateral syntaxin isoforms. STX3-mediated SNARE heterotetramer assembly bridges post-Golgi cargo sorting and apical membrane fusion, balancing polarized secretion throughput according to epithelial secretory demand. STX3 participates in mucosal mucin release, ion transporter delivery and epithelial barrier maintenance. Deficient STX3 expression causes loss of cell polarity and mis-targeted cargo trafficking. Therefore, STX3 represents a pivotal research target for polarized SNARE study and mucosal barrier compound screening.
Fig. 1 Schematic illustrating STX3 expression changes and downstream pro-inflammatory cytokine secretion under different microbial stimuli in dendritic cell lines.1
The biological functions of STX3 are focused on vesicle SNARE heteromer assembly, apical vesicle fusion and epithelial polarity control:
Creative Biolabs offers high-quality STX3 proteins through optimized expression systems, including full-length apical syntaxin and isolated coiled-coil SNARE domain variants. These products retain native vesicle SNARE pairing biological activity, suitable for polarized trafficking interaction assays and mucosal modulator screening. All STX3 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered STX3 stable cell lines, including overexpression and blank control models. These cell lines are optimized for apical SNARE profiling and polarized trafficking functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
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High-specificity recombinant antibodies targeting STX3 are developed via advanced antibody engineering technologies. These antibodies are validated for apical membrane localization detection and mucosal epithelial profiling, and can be combined with apical vesicle markers to analyze complete STX3 SNARE complexes in epithelial cell models.
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Beyond catalog products, Creative Biolabs offers specialized custom services for STX3 research:
STX3 is an apical epithelial target SNARE that pairs with vesicular SNAREs to mediate polarized apical cargo exocytosis.
STX3 is the core SNARE establishing epithelial apical polarity and controlling mucosal secretory cargo sorting.
No, all STX3 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length STX3 syntaxin proteins, isoform-specific detection antibodies and custom stable cell lines for epithelial trafficking research.
STX3 proteins are validated via apical vesicle SNARE heterocomplex binding functional testing.
