Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Syntaxin 5 (STX5) is an integral cis-Golgi SNARE protein encoded by STX5 gene, broadly expressed in secretory cell populations, localized exclusively to cis-Golgi membrane compartments. Distinct from plasma membrane syntaxin paralogs, STX5 carries conserved coiled-coil SNARE domains that mediate specific pairing with ER-derived vesicle SNARE subunits, controlling accurate membrane fusion and directional cargo delivery from endoplasmic reticulum to Golgi stacks. Under basal biosynthetic conditions, steady STX5 expression maintains orderly constitutive protein transport without vesicle accumulation defects. Upon elevated secretory demand, STX5 incorporates into target membrane complexes to accelerate SNARE heteromer assembly and anterograde cargo shuttling. Unlike ubiquitous syntaxins with broad post-Golgi trafficking roles, STX5 exhibits specialized ER-Golgi transport functions that cannot be fully compensated by other syntaxin family members, linking SNARE complex formation to canonical early secretory pathways. Loss of functional STX5 blocks ER-to-Golgi cargo transit and causes intracellular precursor protein retention, while elevated STX5 activity accelerates unregulated vesicle fusion, establishing STX5 as a core research target for Golgi SNARE biology and secretory modulator screening.
STX5 executes target membrane SNARE function embedded within cis-Golgi lipid bilayers, utilizing conserved coiled-coil helical motifs to selectively interact with COPII vesicle SNARE partners. Conserved interaction regions restrict binding to ER-derived vesicle subunits, separating its functional spectrum from late secretory syntaxins. STX5-mediated SNARE assembly bridges ER cargo packaging and cis-Golgi processing, balancing transport throughput relative to cellular biosynthetic load. STX5 participates in glycoprotein maturation, membrane lipid circulation and constitutive secretory protein sorting. Deficient STX5 expression disrupts early secretory trafficking and impairs mature secretory cargo formation. Therefore, STX5 represents a pivotal research target for intracellular transport protein study and secretory pathway modulator screening.
Fig. 1 Model of COPII vesicle biogenesis for general cargo and large fibrillar collagens (Col I/Col VII), followed by STX5-dependent SNARE-mediated fusion of collagen carriers with cis-Golgi stack.1
The biological functions of STX5 are focused on vesicle SNARE heteromer assembly, ER-Golgi membrane fusion and secretory cargo regulation:
Creative Biolabs offers high-quality STX5 proteins through optimized expression systems, including full-length Golgi syntaxin and isolated coiled-coil SNARE domain variants. These products retain native SNARE pairing biological activity, suitable for SNARE interaction assays and secretory pathway screening. All STX5 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered STX5 stable cell lines, including overexpression and blank control models. These cell lines are optimized for Golgi SNARE expression profiling and anterograde trafficking functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting STX5 are developed via advanced antibody engineering technologies. These antibodies are validated for cis-Golgi membrane localization detection and secretory tissue profiling, and can be combined with vesicle marker reagents to analyze complete STX5 SNARE complexes in biosynthetic cell models.
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Beyond catalog products, Creative Biolabs offers specialized custom services for STX5 research:
STX5 is a cis-Golgi syntaxin SNARE protein that forms heteromeric complexes with vesicle SNAREs to mediate ER-to-Golgi cargo fusion.
STX5 acts as a critical link between ER vesicle delivery and Golgi cargo processing, governing the early secretory pathway.
No, all STX5 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length STX5 Golgi syntaxins, isoform-specific detection antibodies and custom stable cell lines for intracellular trafficking research.
STX5 proteins are validated via SNARE heterocomplex binding functional testing.
