Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Sad1 and UNC84 domain containing 2 (SUN2) is an integral inner nuclear membrane structural protein encoded by the SUN2 gene, belonging to the SUN-domain protein family and acting as the core inner nuclear subunit of LINC complexes that bridge nuclear lamina and cytoplasmic cytoskeleton networks. SUN2 is ubiquitously expressed across all somatic cell types, with evolutionarily conserved C-terminal SUN ligand-binding domains located in the perinuclear space and N-terminal lamina-interacting domains located on the nucleoplasmic side across species, serving as an essential modulator for LINC complex assembly, nuclear mechanical anchoring and intracellular force transmission. SUN2-mediated intermembrane linkage activity exerts decisive effects on sustaining stable nuclear positioning, balancing cytoskeleton-derived mechanical stress and maintaining intact nuclear architecture under physiological conditions. Furthermore, SUN2 coordinates downstream signaling cascades governing cell migration, nuclear gene expression tuning and cellular mechanical stress adaptation to safeguard steady tissue structural integrity. Distinct from other SUN paralogs with divergent tissue expression and binding affinity profiles, SUN2 carries unique non-redundant duties in universal LINC complex formation and widespread nuclear-cytoskeleton coupling, rendering it indispensable for regular nuclear positioning, mechanotransduction signaling and overall cellular structural stability.
SUN2 executes biological functions through anchoring to the nuclear lamina via its N-terminal nucleoplasmic domain while projecting its conserved C-terminal SUN domain into the perinuclear space to bind the KASH domains of outer nuclear membrane proteins, forming continuous physical linkages between the nuclear interior and cytoplasmic cytoskeleton to transmit mechanical force across the nuclear envelope and stabilize organelle spatial positioning. Its conserved SUN domain mediates LINC complex assembly and force-bearing intermembrane crosslinking, enabling precise tuning of cellular mechanotransduction intensity and nuclear positioning signal transmission. SUN2-dependent signaling sustains systemic cellular mechanical equilibrium, covering intact LINC complex linkage cycles, coordinated nuclear-cytoskeleton force transmission and persistent nuclear architecture surveillance. SUN2 participates in an extensive spectrum of biological processes, such as LINC complex structural assembly, nucleus-cytoskeleton mechanical coupling, cell migration regulation and mechanosensitive transcriptional modulation. Loss-of-function or mislocalized SUN2 severely disrupts nuclear envelope structural integrity, disturbs intracellular mechanical signal transduction and elevates susceptibility to laminopathy-related degenerative lesions and migratory developmental defects. Therefore, SUN2 constitutes a pivotal research target for investigating nuclear envelope structural biology, cellular mechanophysiology and laminopathy disease pathogenic mechanisms.
Fig. 1 SUN2-containing LINC complexes bridge nuclear lamina and cytoplasmic cytoskeleton in somatic cells, while SUN-KASH5 mediates telomere-microtubule linkage during meiosis.1
The biological functions of SUN2 are focused on SUN-domain mediated LINC complex formation, nuclear lamina anchoring and intermembrane mechanical force transmission:
Creative Biolabs offers high-quality SUN2 proteins via optimized expression systems, covering full-length SUN2 and isolated SUN-domain functional variants. These products retain native spatial conformation and intrinsic LINC-complex binding biological activity, suitable for nuclear envelope structural interaction analysis, mechanotransduction pathway studies and small molecule compound screening targeting laminopathy degenerative disorders. All SUN2 proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered SUN2 stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for nuclear envelope structural research, cellular mechanical phenotype observation and mechanoprotective compound response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
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High-specificity recombinant antibodies targeting SUN2 are developed with advanced antibody engineering workflows, without cross-reactivity against other SUN-domain family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, inner nuclear membrane localization detection, LINC complex binding interaction assessment and laminopathy research, enabling precise characterization of SUN2 expression patterns, subcellular nuclear envelope distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for SUN2 research:
SUN2 is an inner nuclear membrane SUN-domain protein that assembles LINC complexes through its N-terminal nucleoplasmic domain and C-terminal SUN domain in the perinuclear space, physically linking the nuclear lamina to the cytoplasmic cytoskeleton for mechanical signal transduction.
SUN2 exerts irreplaceable control over nuclear envelope structural integrity and cellular mechanotransduction; functional defects induce laminopathy and abnormal nuclear positioning, establishing it as a vital research target.
No, all SUN2 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include SUN2 proteins, high-specificity recombinant antibodies and custom stable cell lines for nuclear envelope and cellular mechanophysiology research.
SUN2 proteins undergo functional verification via KASH-domain binding capacity assessment, SUN-domain conformational analysis and LINC complex structural assembly stability evaluation.
