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TNFRSF13B

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Background

TNF receptor superfamily member 13B (TNFRSF13B, also known as TACI) is a type III transmembrane receptor encoded by the TNFRSF13B gene, selectively expressed on mature B cells and plasma cells. Its extracellular cysteine-rich tandem motifs bind trimeric BAFF and APRIL; ligand crosslinking triggers receptor oligomerization and activates canonical & non-canonical NF-κB signaling via cytoplasmic adaptors.

Under steady immune conditions, moderate TACI signaling maintains peripheral B cell pools, mediates Ig class switching and sustains long-lived plasma cell antibody secretion. Upon pathogen stimulation, elevated BAFF/APRIL amplifies this pathway to expand antigen-specific B clones. Loss-of-function TNFRSF13B mutations weaken antibody production and induce common variable immunodeficiency, while overactive signaling accumulates autoreactive B cells and drives autoimmune inflammation. As illustrated in the schematic, germline TACI mutation impairs B cell activation and plasma differentiation while elevating early self-reactivity, making TNFRSF13B a core research target for B cell biology and humoral immune disorder mechanism research.

Fig. 1 Pathway schematic about TACI pathogenic mutation in B cells, suitable for genotypic-phenotypic correlation analysis and autoimmune susceptibility mechanism research. (OA Literature)Fig. 1 Germline mutation on TNFRSF13B yields dysfunctional TACI protein, impairing B lymphocyte activation, antibody release and plasma cell maturation, meanwhile raising early-stage autoreactive risk inside B cells.1

TNFRSF13B Protein Function: Core Roles in BAFF/APRIL Sensing, B Cell Maturation and Antibody Class Switching

The biological functions of TNFRSF13B are focused on dual BAFF/APRIL ligand recognition, NF-κB immune signaling and plasma cell differentiation control:

  • Dual Ligand Binding: Specifically recognizes both BAFF and APRIL trophic cytokines to transmit B cell survival signals.
  • NF-κB Signal Activation: Recruits cytoplasmic adaptors to trigger transcriptional programs supporting B cell maturation and antibody production.
  • Immunoglobulin Class Switching: Governs efficient conversion from IgM to IgG, IgA and IgE antibody isotypes in activated B cells.
  • Context-Dependent Plasmablast Regulation: TACI may support activated B cell and plasmablast functional responses under specific immune microenvironment conditions.
  • Disease Relevance: TNFRSF13B loss causes primary immunodeficiency, while hyper-signaling drives autoimmune B cell expansion.

TNFRSF13B Protein Product

Creative Biolabs offers high-quality TNFRSF13B proteins through optimized expression systems, including full-length membrane receptor and isolated extracellular ligand-binding domain variants. These products retain native conformational characteristics and BAFF/APRIL dual-ligand binding biological activity, suitable for TNF receptor-ligand interaction assays and B cell immune regulatory mechanism research. All TNFRSF13B proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.

TNFRSF13B Protein Product

Not finding the membrane protein product you need? Contact us to start your one-stop custom service!

TNFRSF13B Stable Cell Line Product

Creative Biolabs provides custom-engineered TNFRSF13B stable cell lines, including wild-type and loss-of-function mutant control models. These cell lines are optimized for BAFF/APRIL signal profiling and B cell differentiation functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.

TNFRSF13B Stable Cell Line Product

Not finding the stable cell line product you need? Contact us to start your one-stop custom service!

TNFRSF13B Recombinant Antibody Product

High-specificity recombinant antibodies targeting TNFRSF13B are developed via advanced antibody engineering technologies, with no cross-reactivity with other TNFRSF BAFF receptor paralogs. These antibodies are validated for B lymphocyte surface localization detection and lymphoid tissue expression profiling, and can be combined with BAFF/APRIL detection reagents to analyze complete receptor-ligand signaling complexes in humoral immune research models.

TNFRSF13B Recombinant Antibody Product

Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!

Product Features

  • Native Dual-Ligand Binding Activity: Preserves intact BAFF and APRIL recognition capacity for B cell humoral immunity research.
  • TNFRSF Isoform Specificity: Eliminates non-specific cross-recognition of BR3 and other TNF superfamily receptors.
  • Immunology Compatibility: Optimized reagent series for immunodeficiency and autoimmune B cell phenotype research workflows.
  • Comprehensive Customization Support: Facilitates end-to-end development of customized proteins, antibodies and stable cell lines to address B cell TNF receptor research demands.

Custom TNFRSF13B Research Services

Beyond catalog products, Creative Biolabs offers specialized custom services for TNFRSF13B research:

  • Custom TNFRSF13B Protein Production: Tailored expression of mutant and tagged TNFRSF13B constructs for BAFF/APRIL ligand binding affinity analysis.
  • Custom Antibody Development: Generation of TNFRSF13B-specific antibodies for mature B cell and plasma cell immunostaining.
  • Stable Cell Line Engineering: Construction of TNFRSF13B-modified cell models for NF-κB signaling and antibody class-switch research.
  • Functional Assay Development: Custom design of BAFF-dependent B cell survival and immunoglobulin secretion detection workflows.

Frequently Asked Questions (FAQ)

  1. What is the primary function of TNFRSF13B?

    TNFRSF13B/TACI is a dual BAFF/APRIL receptor expressed on B cells that drives NF-κB signaling to support B cell maturation, antibody class switching and plasma cell survival.

  2. Why is TNFRSF13B a significant research target?

    TACI/TNFRSF13B mediates BAFF/APRIL-driven B cell maturation and antibody class switching. Its dysfunction causes immunodeficiency or autoimmunity, making it critical for immune balance and disorder mechanism research.

  3. Are Creative Biolabs' TNFRSF13B products suitable for clinical use?

    No, all TNFRSF13B products and services are strictly for research use only, not intended for clinical diagnosis or treatment.

  4. What types of TNFRSF13B products does Creative Biolabs offer?

    Offerings include full-length TNFRSF13B membrane receptor proteins, receptor-specific detection antibodies and custom stable cell lines for B cell immunology research.

  5. How are TNFRSF13B proteins validated for activity?

    TNFRSF13B proteins are validated via dual BAFF and APRIL ligand binding interaction testing.

Reference
  1. Coimbra, Miguel T., José Silvano, and La Salete Martins. "Medical Challenges of a Common Variable Immunodeficiency With a TNFRSF13B Gene Mutation in a Simultaneous Kidney and Pancreas Transplant Recipient." Cureus 15.8 (2023): e44211. Under Open Access license CC BY 4.0, without modification. https://doi.org/10.7759/cureus.44211
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