Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
TNF receptor superfamily member 17 (TNFRSF17) is a single-pass transmembrane glycoprotein encoded by the TNFRSF17 gene, composed of multiple extracellular cysteine-rich receptor domains, a transmembrane segment and cytoplasmic death-domain-associated signaling tail, and acts as an obligate accessory subunit for B cell-specific TNF ligand receptor complexes. TNFRSF17 is widely expressed across mature B lymphocytes, plasma cells and lymphoid stromal cell populations, serving as a core scaffold mediating receptor heterodimer formation and downstream lymphoid survival kinase recruitment upon TNF ligand stimulation.
TNFRSF17 exerts its biological effects through stable heterodimeric assembly with primary TNF receptor chains, a mechanism that modulates ligand binding stability and intracellular lymphoid signal cascade activation efficiency. Unlike ligand-binding primary TNF receptors, TNFRSF17 cannot bind TNF superfamily cytokines independently and relies on receptor dimerization to initiate full signal output; it recruits cytoplasmic signal mediators to assembled receptor complexes, uncoupling extracellular ligand recognition from intracellular lymphoid transcription factor activation and sustaining persistent lymphocyte survival signals. This dual regulation modulates the intensity of lymphoid proliferative responses after cytokine stimulation, fine-tuning local B cell activation and survival mediator secretion levels, while sustained abnormal TNFRSF17-mediated signal transmission drives excessive lymphoid expansion and proliferative lesions. TNFRSF17 participates in key physiological and pathological processes including B cell maturation, humoral immune maintenance, cytokine-mediated lymphoid hyperplasia and chronic lymphoproliferative disorders. Dysregulation of TNFRSF17 expression or receptor dimerization capacity is closely associated with unregulated lymphocyte proliferation and impaired humoral immune defense, making TNFRSF17 a crucial research target for TNF superfamily signaling, B cell immunity and lymphatic disease research.
Fig. 1 Overview of BAFF/APRIL ligand-receptor network with TNFRSF17 (BCMA), showing receptor expression on immune cells and associated immune functions.1
The biological functions of TNFRSF17 are focused on TNF receptor heterodimerization, lymphoid survival signal propagation and humoral immune balance:
Creative Biolabs offers high-purity TNFRSF17 proteins through optimized heterologous expression systems, including full-length TNFRSF17 and isolated extracellular cysteine-rich domain variants with modified glycosylation status. These products retain native conformational characteristics, suitable for B cell signaling research, receptor complex interaction detection, and small molecule lymphoid regulatory drug screening for lymphoproliferative disorder research. All TNFRSF17 proteins undergo strict quality control, including purity analysis and biological activity validation to ensure biological function.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered TNFRSF17 stable cell lines, including overexpressing and knockdown models in lymphoid and stromal cell models. These cell lines are optimized for studying TNFRSF17-mediated receptor heterodimer assembly mechanisms, B cell signal cascade dynamics, and lymphoid regulatory compound sensitivity. Each cell line undergoes stringent validation, including stable expression detection and functional integrity verification.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting TNFRSF17 are developed via advanced antibody engineering technologies. These antibodies are validated for multiple applications, including immunofluorescence for TNFRSF17 membrane localization, Western blot for expression analysis, and co-immunoprecipitation for TNFRSF17-receptor complex research, enabling precise analysis of TNFRSF17 expression, subcellular localization and functional regulation.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for TNFRSF17 research:
TNFRSF17 is a B cell TNF co-receptor that directly heterodimerizes with BAFF/APRIL primary receptors to modulate cytokine-driven lymphocyte survival signal amplitude, balance lymphoid tissue proliferative dynamics, and mediate sustained humoral immune activation upon ligand stimulation.
TNFRSF17 is a core regulator of BAFF/APRIL lymphoid signaling and humoral immune homeostasis, and its dysregulation is associated with unregulated B cell expansion and chronic lymphoproliferative lesions. It is a critical target for TNF superfamily and B cell immunity research.
No, all TNFRSF17 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include TNFRSF17 proteins (full-length, extracellular cysteine-rich domain variants), specific recombinant antibodies, and custom stable lymphoid cell lines, supporting B cell and lymphoproliferative disorder research.
TNFRSF17 proteins are validated by TNF receptor heterodimer binding assays and lymphoid survival signal regulation verification to ensure native regulatory function in humoral immune research.
