Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
TNF superfamily member 13b (TNFSF13B, BAFF) is secreted and membrane-tethered TNF ligand encoded by TNFSF13B gene, produced by myeloid and stromal cells, acting on B lymphocyte surface receptors. Distinct from other TNF cytokines, TNFSF13B binds three distinct B cell receptors to support naive B cell survival, germinal center progression and plasma cell differentiation. Under baseline immune status, low ligand concentration maintains physiological B cell compartment size without autoantibody expansion. Upon inflammatory stimulation, elevated TNFSF13B extends survival of autoreactive B cell clones and boosts immunoglobulin secretion. Unlike broad immune TNF factors, TNFSF13B carries B cell lineage-specific homeostatic functions that cannot be fully replaced by other TNF family members, linking stromal-derived ligand signaling to humoral tolerance pathways. Loss of functional TNFSF13B drastically reduces mature B cell pools, while ligand overabundance drives autoantibody-mediated pathology, establishing TNFSF13B as a core research target for B cell TNF ligand biology and autoimmune compound screening.
TNFSF13B functions as soluble homotrimeric ligand, utilizing conserved TNF superfamily folds to engage BAFF-R, TACI and BCMA receptors selectively expressed on B lineage cells. Conserved trimerization motifs separate its B-cell-restricted binding profile from systemic inflammatory TNF paralogs. TNFSF13B receptor ligation bridges stromal cytokine secretion and B cell anti-apoptotic transcriptional programs, balancing peripheral B cell repertoire size and autoantibody output according to inflammatory stimulus intensity. TNFSF13B participates in naive B cell maturation, memory B cell maintenance and plasma cell generation. Deficient TNFSF13B expression results in severe peripheral B cell lymphopenia. Therefore, TNFSF13B represents a pivotal research target for humoral immune ligand study and anti-autoimmune compound screening.
Fig. 1 Schematic of TNFSF13B (BAFF)-dependent B cell developmental trajectory from bone marrow immature B cells through splenic transitional checkpoints, germinal center differentiation to memory and long-lived plasma cells, with distinct stage-specific expression of BAFFR, TACI and BCMA.1
The biological functions of TNFSF13B are focused on B cell receptor trimer binding, anti-apoptotic signaling and antibody control:
Creative Biolabs offers high-quality TNFSF13B proteins through optimized expression systems, including full-length membrane precursor and soluble trimer variants. These products are suitable for B cell receptor interaction and humoral modulator screening. All TNFSF13B proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered TNFSF13B stable cell lines, including overexpression and blank control models. These cell lines are optimized for TNF ligand profiling and B cell survival signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting TNFSF13B are developed via advanced antibody engineering technologies. These antibodies are validated for stromal/myeloid secretion profiling and B cell co-staining, and can be combined with BAFF-R detection reagents to analyze ligand-receptor signaling complexes in lymphocyte models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for TNFSF13B research:
TNFSF13B (BAFF) is a homotrimeric TNF ligand that binds three B cell receptors to deliver anti-apoptotic signals supporting mature B cell survival and antibody production.
TNFSF13B is the central cytokine governing peripheral B cell homeostasis and is a key driver of autoantibody-mediated autoimmune disorders.
No, all TNFSF13B products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length TNFSF13B ligand proteins, isoform-specific detection antibodies and custom stable cell lines for humoral immunity research.
TNFSF13B proteins are validated via multi-B cell receptor binding functional testing.
