Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
TNF superfamily member 14 (TNFSF14, LIGHT) is a dual membrane-bound and secreted TNF ligand encoded by TNFSF14 gene, expressed in T lymphocytes, dendritic cells and stromal subsets, localized to plasma membrane and interstitial fluid compartments. Distinct from other TNF cytokines, TNFSF14 engages two distinct TNF receptors to coordinate endothelial upregulation of adhesion molecules and drive lymphoid tissue organogenesis. Under steady immune conditions, basal TNFSF14 expression maintains mild vascular permissiveness without excessive leukocyte infiltration. Upon inflammatory or antigenic stimulation, accumulated ligand triggers endothelial signaling to boost leukocyte recruitment and support germinal center development. Unlike general inflammatory TNF factors, TNFSF14 carries lymphoid-organizing functions that cannot be fully substituted by other superfamily members, linking lymphocyte-stroma crosstalk to secondary lymphoid tissue assembly pathways. Loss of functional TNFSF14 impairs lymphoid structure formation and dampens regional immune responses, while sustained ligand expression amplifies vascular inflammatory recruitment, establishing TNFSF14 as a core research target for lymphoid TNF ligand biology and autoimmune modulator screening.
TNFSF14 executes homotrimeric ligand function embedded in lymphocyte membranes and extracellular space, utilizing conserved TNF fold motifs to selectively bind HVEM and LTβR receptor ectodomains. Conserved trimerization interfaces separate its receptor selectivity from canonical inflammatory TNF paralogs. TNFSF14-mediated receptor clustering bridges lymphocyte-stromal contact and endothelial transcriptional reprogramming, balancing lymphoid organ growth and tissue inflammatory magnitude according to antigen exposure load. TNFSF14 participates in lymph node genesis, mucosal immune cell recruitment and chronic autoimmune inflammation. Deficient TNFSF14 expression disrupts secondary lymphoid tissue architecture and weakens adaptive immune surveillance. Therefore, TNFSF represents a pivotal research target for lymphotropic TNF ligand study and anti-autoimmune compound screening.
Fig. 1 Schematic of TNFSF14 (LIGHT) signaling interactome: homotrimeric LIGHT binds LTβR and HVEM to trigger immune activation; HVEM also forms cis complex with BTLA, while CD160 and soluble DcR3 antagonize LIGHT-mediated signal transduction.1
The biological functions of TNFSF14 are focused on HVEM/LTβR binding, endothelial activation and lymphoid organ control:
Creative Biolabs offers high-quality TNFSF14/LIGHT proteins, including full-length membrane-bound, soluble, and multimerized constructs. These products are suitable for HVEM and LTβR binding studies, while receptor activation may be evaluated using appropriate multivalent formats and cell-based NF-κB assays. All products undergo applicable quality control to support reliable research use.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered TNFSF14 stable cell lines, including overexpression and blank control models. These cell lines are optimized for TNF ligand profiling and endothelial inflammatory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting TNFSF14 are developed via advanced antibody engineering technologies. These antibodies are validated for lymphocyte membrane and interstitial fluid localization detection and lymphoid tissue expression profiling, and can be combined with HVEM/LTβR detection reagents to analyze complete ligand-receptor complexes in immune cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for TNFSF14 research:
TNFSF14 is a homotrimeric TNF ligand that binds HVEM and LTβR receptors to drive endothelial activation and secondary lymphoid organ formation.
TNFSF14 links lymphocyte-stromal communication to lymphoid tissue development and chronic vascular inflammation in autoimmune conditions.
No, all TNFSF14 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length TNFSF14 ligand proteins, isoform-specific detection antibodies and custom stable cell lines for lymphoid immunity research.
TNFSF14 proteins are validated via HVEM/LTβR dual receptor binding functional testing.
