Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Tyrosinase-related protein 1 (TYRP1) is a type I melanosomal transmembrane glycoprotein encoded by the TYRP1 gene, selectively expressed in melanocytes and melanoma cells and localized to mature pigment organelles, where it participates in melanosome function and melanogenesis. Although DHICA oxidase activity has been reported for Tyrp1 in mouse experimental systems, recombinant human TYRP1 has not demonstrated an established DHICA oxidase activity. TYRP1 has also been implicated in the regulation and stabilization of tyrosinase, thereby supporting normal melanosomal function and pigment production.
Human TYRP1 contains a binuclear zinc-binding site rather than a conserved copper-containing catalytic pocket, and its precise catalytic function remains under investigation. TYRP1 may influence melanogenesis through its roles in melanosome organization and interactions with tyrosinase. TYRP1 variants can disrupt melanosome function and pigmentation, but they should not be assumed to cause DHICA quinone accumulation, oxidative stress or apoptotic death through a defined catalytic mechanism. TYRP1 participates in epidermal pigment formation and has been widely investigated in melanocyte biology and cutaneous melanoma, making it an important research marker for melanogenesis and melanoma-related studies.
Fig. 1 TYRP1 acts as DHICA oxidase to drive eumelanin biosynthesis together with tyrosinase and TYRP2 inside melanosomes, distinct from cysteine-dependent pheomelanin pathway.1
The biological functions of TYRP1 are focused on copper-dependent DHICA catalytic oxidation and tyrosinase stabilization:
Creative Biolabs offers high-quality TYRP1 proteins through optimized heterologous expression systems, including species-defined full-length proteins, recombinant luminal-domain constructs and selected sequence variants where available. These products are suitable for TYRP1 identity, binding, antibody characterization and expression-related studies, with functional claims limited to product-specific validation data. All TYRP1 batches undergo strict quality control to ensure consistent performance and reliable application across melanocyte and melanoma research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered TYRP1 stable cell lines, including overexpressing and knockdown melanocyte/melanoma cell research models. These cell lines are optimized for melanin synthesis pathway investigation and melanoma therapeutic compound potency testing. Each cell line undergoes stringent validation to ensure stable melanosomal enzyme expression profiles and consistent catalytic functional performance in diverse experimental contexts.
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High-specificity recombinant antibodies targeting TYRP1 are developed via advanced antibody engineering technologies, with no cross-reactivity with tyrosinase or TYRP2 paralogs. These antibodies are validated for melanosome immunofluorescence localization detection, Western blot expression quantification and co-immunoprecipitation analysis of melanogenic enzyme complexes, enabling precise characterization of TYRP1 expression levels and subcellular distribution under physiological and melanoma pathological conditions.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for TYRP1 research:
TYRP1 is a melanosomal copper-dependent enzyme that catalyzes DHICA oxidation into mature eumelanin, stabilizes tyrosinase, and protects melanocytes from toxic quinone accumulation.
TYRP1 is essential for normal melanin synthesis and melanocyte survival, and its dysregulation correlates with melanoma progression. It is a critical core research target for pigment cell biology and melanoma study.
No, all TYRP1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length TYRP1 catalytic proteins, high-specificity recombinant antibodies, and custom stable melanin synthesis reporter cell lines, supporting comprehensive melanogenesis and melanoma research projects.
TYRP1 proteins undergo product-specific identity and quality-control testing, with binding or expression-based validation performed where applicable. Melanogenic enzymatic activity is not claimed unless demonstrated under defined species and assay conditions.
