Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
U22 glycoprotein is a betaherpesvirus-encoded integral membrane glycoprotein encoded by viral U22 open reading frame, expressed on infected host cell and viral envelope surfaces, localized exclusively to infected cell plasma and viral envelope lipid bilayers. Distinct from other viral envelope glycoproteins, U22 relies on extracellular glycosylated ectodomains to engage host immune cell surface receptors, while simultaneously modulating chemokine signaling pathways to redirect leukocyte recruitment for sustained viral replication. Under early infection stages, low-level U22 expression mediates subtle immune cell recruitment without robust inflammatory clearance responses. Upon viral late gene activation, abundant U22 envelope glycoprotein drives targeted immune cell chemotaxis to expand susceptible host cell pools and facilitate viral dissemination. Unlike structural viral glycoproteins solely mediating cell entry, U22 bears specialized immunomodulatory immune evasion functions that cannot be fully compensated by other viral glycoproteins, linking viral envelope presentation directly to host leukocyte recruitment and persistent infection pathways. Loss of functional U22 glycoprotein blunts viral capacity to remodel local immune microenvironments and restricts viral tissue spread, while sustained U22 expression suppresses anti-viral innate immune activation, establishing U22 as a core research target for viral glycoprotein immunology and anti-herpesvirus compound screening.
Fig. 1 Genomic organization of HHV-6B roseolovirus U20–U26 gene cluster and three-dimensional crystal structures of encoded U2 family proteins including U22 envelope glycoprotein.1
The biological functions of U22 glycoprotein are focused on glycan-dependent host receptor engagement, leukocyte chemotaxis modulation and anti-viral immune suppression:
Creative Biolabs offers high-quality U22 glycoproteins through optimized expression systems, including full-length viral envelope glycoprotein and isolated glycosylated ectodomain variants. These products suitable for viral-host interaction and anti-viral compound screening. All U22 glycoproteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered U22 stable cell lines, including overexpression and blank control models. These cell lines are optimized for viral glycoprotein expression profiling and host immune receptor interaction functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting U22 glycoprotein are developed via advanced antibody engineering technologies, with no cross-reactivity with other herpesvirus envelope glycoproteins. These antibodies are validated for viral envelope and infected cell membrane localization detection and viral tissue expression profiling, and can be combined with host chemokine receptor detection reagents to analyze complete U22-host receptor complexes in infected cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for U22 research:
U22 is a viral envelope glycoprotein that binds host immune receptors to remodel leukocyte recruitment and mediate viral immune evasion.
U22 acts as a critical link between viral envelope presentation and local immune microenvironment remodeling, sustaining persistent herpesvirus infection.
No, all U22 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length U22 viral glycoproteins, isoform-specific detection antibodies and custom stable cell lines for viral immune evasion research.
U22 glycoproteins are validated via host immune receptor binding functional testing.
