Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Vezatin(VEZT) is a double-membrane integrated scaffold protein encoded by VEZT gene, which is widely expressed in the adhesion junction area between epithelial cells and sensory cells, anchored between cell membrane and cytoskeleton of intracellular actin, and is the core component to maintain the stability of cell junction structure. Different from the classical cadherin adhesion molecule, VEZT contains multiple binding motifs at the cell end, which can simultaneously bind catenin complex and non-classical myosin VIIA to construct a stable mechanical connection system and help cells maintain the integrity of adhesion structure under tension stress. Under the physiological steady state of epithelial tissue, VEZT is continuously and stably expressed, which can lock the functional complex of E-cadherin-catenin, stabilize the barrier structure of epithelial monolayer, effectively inhibit the discrete migration of cells and maintain the order of tissue structure. However, in epithelial tumors such as gastric cancer and endometrial cancer, epigenetic silencing or microRNA-mediated transcription inhibition will significantly down-regulate the expression of VEZT, directly destroy the mechanical stability of cell connection, lead to the loss of cell polarity, abnormal enhancement of migration and invasion ability, and drive the malignant progress of the tumor. Other connective scaffold proteins can't compensate for VEZT's unique myosin-catenin bridging regulation function. Overexpression of VEZT can significantly inhibit the invasion and metastasis of tumor cells, and the loss of VEZT function will cause the disintegration of cochlear hair cell connective structure and induce hearing damage, which is an irreplaceable core target for the study of biological mechanism of adhesion connection and targeted screening of epithelial tumors.
VEZT is located in the lipid bilayer of epithelial cell membrane, which plays an exclusive bridging function of connection mechanics. By means of two independent cytoplasmic binding domains, it anchors the cadherin‑catenin complex and myosin VIIA motor protein associated with actin, respectively, and realizes the mechanical coupling between cell connection and cytoskeleton. Its unique characteristics of tension‑resistant scaffold form significant functional differentiation with transmembrane proteins which only undertake a single adhesion function, and form the core hub for buffering mechanical stress and maintaining structural stability in the adherens junction system. VEZT‑mediated cytoskeleton‑adhesion structure linkage mechanism can dynamically balance the structural stability of epithelial barrier and the plasticity of cell migration according to the change of tissue mechanical load, and adapt to the needs of tissue physiological remodeling. This molecule is widely involved in embryonic epithelial morphogenesis and cochlear sensory cell structure maintenance. Besides its well‑characterized role as adherens‑junction scaffold within epithelial and inner‑ear sensory cells, VEZT (vezatin) also participates in postsynaptic signal regulation in neurons by modulating PKA‑AKAP150‑GluA1 receptor recycling pathway. Therefore, VEZT serves as a multi‑functional scaffold for cytoskeleton‑related research across multiple cell types.
Fig. 1 Schematic illustrating the regulatory role of VEZT (vezatin) in postsynaptic PKA‑AKAP150‑GluA1‑dependent AMPA‑receptor trafficking within neuronal dendritic spines.1
The biological functions of dual-transmembrane VEZT scaffold are fully focused on catenin-myosin linkage and malignant migration suppression:
Creative Biolabs offers high-quality VEZT proteins through optimized epithelial expression systems, including full-length dual-pass scaffold and isolated cytoplasmic binding domain variants. These products retain native catenin-myosin co-binding activity, suitable for junction stability and anti-tumor migration screening assays. All VEZT proteins undergo strict quality control to ensure consistent performance and reliable application across epithelial research platforms.
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Creative Biolabs provides custom-engineered VEZT stable cell lines, including wild-type tumor suppressor overexpression and blank empty vector control models. These cell lines are optimized for adherens junction scaffold profiling and migratory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles during long-term epithelial monolayer culture, and can be widely deployed for gastric cancer inhibitory compound screening experiments.
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High-specificity recombinant antibodies targeting VEZT are developed via advanced antibody engineering technologies. These antibodies are validated for epithelial intercellular junction localization detection and gastric tissue expression profiling, and can be combined with E-cadherin detection reagents to analyze complete VEZT adhesion complexes in epithelial cell models.
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Beyond catalog products, Creative Biolabs offers specialized custom services for VEZT research:
VEZT is an adherens junction scaffold linking catenin complexes and myosin VIIA to stabilize epithelial mechanical adhesion.
VEZT acts as a tumor suppressor in gastric cancer, its epigenetic loss drives tumor invasion and metastasis.
No, all VEZT products and services are strictly for research use only, not intended for clinical diagnosis or human therapeutic trials.
Offerings include full-length VEZT junction proteins, isoform-specific detection antibodies and custom stable cell lines for epithelial barrier research.
VEZT proteins are validated via E-cadherin and myosin VIIA dual co-binding functional testing.
