Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Gastrin/cholecystokinin type B receptor |
| Gene Name | CCKBR |
| Uniprot | P32239 (Human); P56481 (Mouse) |
| Synonym | GASR; CCK-B; CCK2R; gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK2 receptor; cholecystokinin-2 receptor; gastrin receptor |
| Background | CCKBR is a type B gastrin receptor that encoded by CCKBR gene. It belongs to the seven-transmembrane domain β-adrenergic receptor superfamily. There are 3 isoforms of the human CCK-BR protein resulted from alternative splicing. The cholecystokinin B receptor (CCKBR) functions mechanistically as a G-protein coupled receptor. Its endogenous ligands encompass gastrin and cholecystokinin (CCK). These are critical neurogastrointestinal peptides exerting complex regulatory influences within both the brain and the gastrointestinal system. Notably, CCKBR constitutes the predominant subtype among central cholecystokinin receptors. Its defining pharmacological characteristic is a high binding affinity demonstrated towards both sulfated and non-sulfated cholecystokinin peptide analogs. |
Creative Biolabs offers a comprehensive range of membrane protein products that empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX257 | NativeExtract™ Human CCKBR Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3581K | MemDX™ Membrane Protein Human CCKBR (Cholecystokinin B receptor) Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
J***m: Creative Biolabs offers great value for money. The company's professionalism and attention to detail were evident throughout the entire ordering process. The shipping was fast, and the packaging was excellent, ensuring that the product arrived in perfect condition.
26/May/2024
With our innovative approaches and comprehensive services, Creative Biolabs is dedicated to advancing CCKBR gene therapy. We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers gene therapy research services. Gene therapy strategies directed towards the cholecystokinin B receptor (CCKBR) often leverage viral vector platforms. These sophisticated delivery vehicles are employed to introduce therapeutic genetic payloads specifically designed to modulate CCKBR expression levels or perturb its intrinsic signaling functions. Furthermore, a specific implementation involves the engineering of adenoviral constructs. Such vectors can be rationally designed for the ectopic expression of selective CCKBR antagonists. Consequently, these expressed antagonists effectively inhibit downstream CCKBR-mediated signal transduction, ultimately contributing to an attenuation of tumor proliferative capacity.
Creative Biolabs offers delivery services using liposomes. Liposomal delivery systems mediating cholecystokinin B receptor (CCKBR)-targeted gene therapy demonstrate considerable efficacy. Specifically, in orthotopic murine models simulating human prostate cancer, this approach achieves significant repression of tumor burden. Furthermore, it demonstrably prolongs subject survival. The encapsulation within liposomes is crucial; it enhances both the stability and the ultimate therapeutic efficacy of the delivered genetic constructs.
Creative Biolabs offers comprehensive and innovative services to drive the development of CCKBR cell therapy. Our commitment to excellence ensures the highest quality and reliability. Please for more services.
Creative Biolabs offers CAR-T cells targeting CCKBR construction services. The cells are engineered to express a chimeric antigen receptor that specifically targets CCKBR on the surface of tumor cells. This method allows for highly specific targeting of cancer cells, reducing off-target effects and improving therapeutic efficacy.
Creative Biolabs offers NK cells targeting CCKBR construction services. Similar to CAR T cells, NK cells can be engineered to express a receptor that specifically targets CCKBR. This enhances their ability to recognize and destroy CCKBR-expressing tumor cells.
As a reliable partner of the top global pharma companies and research agencies, Creative Biolabs applies its expertise in professional membrane protein preparation of demanded formats by all sorts of strategies, with the world's broadest range of knowledge in this area. Currently, a group of experienced scientists in Creative Biolabs is proud to offer legendary membrane protein preparation services. Please feel free to for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
