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Recombinant Mouse Antibody binds selectively to Human CD47, expressed in Chinese Hamster Ovary cells(CHO)
Intact CD47 purified from placenta.
Suitable for use in Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
Tested positive against native antigen.
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Store at -20°C. Avoid multiple freeze/thaw cycles.
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
protein binding; thrombospondin receptor activity;