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ABCA7 Membrane Protein Introduction

Introduction of ABCA7

ABCA7 encoded by ABCA7 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters which transport various molecules across extra- and intracellular membranes. There are seven subfamilies in ABC superfamily named as ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White, respectively. ABCA7 protein belongs to ABC1 subfamily. It is highly expressed in peripheral leukocytes, thymus, spleen, and bone marrow.

Basic Information of ABCA7
Protein Name ATP-binding cassette sub-family A member 7
Gene Name ABCA7
Aliases AD9, ABCX, ABCA-SSN
Organism Homo sapiens (Human)
UniProt ID Q8IZY2
Transmembrane Times 12
Length (aa) 2146
Sequence MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL

Function of ABCA7 Membrane Protein

ABCA7 is an integrated transport protein that transports lipid molecules across extra- and intracellular membranes involved in the regulation of lipid homeostasis within defined microenvironments. In female mice, ABCA7 knockout can significantly reduce visceral fat and serum cholesterol concentrations. It has been reported that ABCA7 plays an essential role in the progression of Alzheimer’s disease (AD). The highest levels of ABCA7 are observed in the hippocampus that is one of the earliest affected regions in the brains of patients with AD, and in microglia cells responsible for cerebral inflammatory responses. Moreover, ABCA7 may be involved in the microglial amyloid-β (Aβ) clearance pathway that is a protective factor for AD. The deficiency of ABCA7 leads to the accumulation of Aβ thereby triggering the pathogenic cascade of AD. Several GWASs (Genome Wide Association Study) have revealed that variants in ABCA7 genes, especially loss-of-function variants, are associated with significant risk for AD. In addition, ABCA7 is also found in a variety of immune cells suggesting a role in immune response. However, the role of ABCA7 in the immune response is unknown.

ABCA7 Membrane Protein Introduction Fig.1 Possible pathogenic pathways mediated by ABCA7 in AD. (Aikawa, 2018)

Application of ABCA7 Membrane Protein in Literature

  1. Ma F.C., et al. Meta-analysis of the association between variants in ABCA7 and Alzheimer's Disease. Journal of Alzheimer Disease Jad. 2018. 63(4): 1261-1267. PubMed ID: 29782324

    The meta-analysis study shows that the loss-of-function variants in ABCA7 are significantly linked to the susceptibility to Alzheimer's Disease.

  2. Almeida J., et al. Updated Meta-analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 variants in Alzheimer's Disease. Journal of Molecular Neuroscience. 2018, 64(3): 471-477. PubMed ID: 29504051

    The meta-analysis study shows that ABCA7 (rs3764650), CR1 (rs6656401), and BIN1 (rs744373) are the risk factors of late-onset Alzheimer's disease (LOAD), while MS4A6A (rs610932) and CLU (rs11136000) are the protective factors.

  3. May P., et al. Rare ABCA7 variants in 2 German families with Alzheimer Disease. Neurol Genet. 2018, 4(2): e224. PubMed ID: 29577078

    The authors identify 2 rare variants in ABCA7 (rs143718918 and rs538591288) are associated with the development of Alzheimer Disease (AD) in 2 German families. These suggest ABCA7 is one of the most relevant genes of AD risk.

  4. Aikawa T., et al. ABCA7 and pathogenic pathways of Alzheimer's Disease. Brain Sci. 2018, 8(2). PubMed ID: 29401741

    The study shows that the dysfunctions of ABCA7 are associated with the AD-related of Alzheimer's disease involved in multiple pathways such as microglial Aβ clearance pathway.

  5. Zhou G., et al. ATP binding cassette subfamily A member 7 rs3764650 polymorphism and the risk of Alzheimer's Disease. Pharmazie. 2017, 72(7): 425-427. PubMed ID: 29441941

    The authors identify the association of ABCA7 rs3764650 polymorphism with the risk of Alzheimer's disease (AD) using a meta-analysis.

ABCA7 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-ABCA7 antibody development services.


As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

Reference

  1. Aikawa T., et al. (2018). ABCA7 and pathogenic pathways of Alzheimer's disease. Brain Sci. 2018, 8(2):27.

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