Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe strategy of displaying heterologous proteins on the surface of live bacterial cells has emerged over the past two decades as a powerful alternative for the development of vaccine candidates. With our extensive experience, Creative Biolabs now offers live bacterial vaccine delivery vehicle development services through the surface display of foreign antigens on the bacterial surfaces. Our platform enables the construction of recombinant microorganisms capable of displaying heterologous proteins in different cellular compartments, improving the antigenic potential of vaccines against viruses, bacteria, parasites, and cancers.
Intrinsic characteristics of bacteria (e.g. lipoteichoic acid in Gram-positive bacteria and lipopolysaccharide in Gram-negative bacteria) can be recognized by pattern recognition receptors (PRRs), which mediate different signaling pathways, leading to inflammatory cytokines production and antimicrobial genes expression. This innate immune response to bacterial pathogens and their effects on the adaptive immune system make attenuated live microorganisms an extremely effective vector for stimulating specific and long-term immune responses against carried antigens. Thus, in addition to the production and delivery of antigens, the innate characteristics of these vectors make them useful immune-stimulating adjuvants.
Creative Biolabs genetically engineers attenuated bacteria to deliver recombinant heterologous antigens, thereby stimulating the host immune system while still providing a good level of safety. These live vectors are capable of stimulating mucosal and humoral and/or cellular system immunity, enabling the delivery of DNA vaccines and immune system stimulating molecules. Recently, these vectors have also been used to develop anti-cancer vaccines, including the delivery of tumor-associated antigens, cytokines, and DNA or RNA molecules.
Two different types of bacteria have been used in order to produce live bacterial vaccines, including attenuated pathogens (such as Gram-negative Salmonella and Gram-positive M. bovis strain BCG), or non-pathogenic commensal or food-grade bacteria (such as S. gordinii and several and lactic acid bacteria). Non-pathogenic or food-grade bacteria which do not invade the host are generally inefficient at generating strong antibody responses.
To date, Creative Biolabs has developed vaccine delivery vectors based on live bacteria from different species through bacterial surface display technology. Creative Biolabs establishes bacterial display systems by using different kinds of anchoring motifs. With our advanced platforms and extensive experience, we are confident in offering the best services and guaranteeing the finest results for our customers all over the world. Please do not hesitate to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
