Our Magic Hybridoma™ Platform allows generation of 50-200 mouse hybridoma clones per hybridoma cell fusion. This platform relies on the novel immunization adjuvant, Magic Mouse Adjuvant, which enables generation of a large number of hybridoma clones in mice using even a trace amount of immunogen for most antigens.
It can be difficult to obtain highly specific and sensitive antibodies that recognize the antigen in its native conformation, e.g. antibodies used in diagnostics assays and antibodies intended for therapeutic purposes, unless there are a large number of candidate antibody clones to be screened, even in cases in which the immunogen is well designed to mimic the conformation of the antigen. In particular, to have an antibody of therapeutic potential requires production of hundreds of binding antibodies first; after that, binders with desired biological functions can be further isolated. Therefore, Magic Hybridoma™ Platform represents an revolutionary method to produce a large number of monoclonal antibodies for each target. Among all research adjuvants and vaccine adjuvants available in the market, Magic Mouse Adjuvant by far is the most efficient mouse adjuvant for all types of immunogens tested, in terms of its rapidness in raising immune responses and the big number of hybridoma clones it can produce. We frequently obtain over 50-200 hybridoma clones per fusion, thus providing the solid basis to isolate functional antibodies.