Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIdentifying immunogenic peptides presented by MHC molecules is a critical bottleneck in vaccine development, cancer immunotherapy, and autoimmune research. Our yeast display-based MHC-peptide discovery service directly addresses this challenge by screening diverse peptide libraries against your MHC allele(s) of interest in a conformation-accurate, eukaryotic expression system.
| The result: high-confidence peptide candidates with validated binding profiles. Whether you are mapping epitopes for T cell engineering or validating neoantigen candidates, this service provides the throughput and precision you need. |
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Identifying immunogenic peptides presented by MHC molecules is a critical bottleneck in vaccine development, cancer immunotherapy, and autoimmune research. Our yeast display-based MHC-peptide discovery service directly addresses this challenge by screening diverse peptide libraries against your MHC allele(s) of interest in a conformation-accurate, eukaryotic expression system.
Improve affinity, stability, or selectivity of existing peptide leads through iterative mutagenesis and selection.
Map binding interfaces and discover competitive peptide ligands.
Study phosphorylation, glycosylation, and other modifications.
Combine bioinformatics and display for intelligently designed libraries.
Standardized procedures plus customized solutions with full-process end-to-end service, enabling you to efficiently obtain high-quality candidate ligands and complete experimental data.
Starting Materials (client provides)
Option A → Peptide target sequence(s) or peptide library (synthetic or NGS-derived)
Option B → MHC allele(s) of interest (Class I or Class II)
Option C → Pre-existing peptide-MHC complex for benchmarking (optional)
Peptide-encoding DNA is fused to MHC molecules and displayed on the yeast surface.
Yeast is grown to support proper MHC folding and peptide exchange.
High-throughput fluorescence-activated cell sorting enriches for yeast displaying stable peptide-MHC complexes.
Additional rounds of sorting under competitive binding conditions increase stringency.
Recovered plasmid DNA from enriched clones is sequenced to identify peptide candidates.
Select hits are re-expressed and tested for binding specificity and thermal stability (optional add-on).
Deliverables
Our Yeast Display Platform is the engine behind this service. Yeast surface display uses Saccharomyces cerevisiae to express proteins of interest (here, peptide-MHC complexes) as fusions with cell wall anchor proteins.
Yeast Display Platform - Creative Biolabs
Relying on international cutting-edge technologies, exclusive core expertise and rich practical experience, we deliver higher-quality and more reliable MHC-peptide ligand discovery services.
Adopting core technical logic from classic literatures, supporting full MHC-I/HLA typing screening; our technical routes are in line with top global research and recognized by both academia and industry.
Self-developed proprietary yeast eukaryotic expression system ensures natural MHC folding and correct disulfide bond assembly, restoring physiological conformation with far higher authenticity and reproducibility than traditional methods.
The team focuses on epitope screening, MHC interaction and tumor immunotherapy target research. We are fully capable of delivering neoantigen identification and TCR-T target projects, complying with both academic publication and industrial standardized delivery requirements.
One-stop full service covering scheme design, library construction, screening analysis, validation and delivery. Customizable human/model organism MHC solutions are available. Simply put forward your research needs to obtain ready-to-use candidate epitopes and complete data.
Explore our complete suite of yeast display technology offerings
Custom library design and construction covering diverse peptide scaffolds and diversities.
High-throughput FACS-based screening against soluble, membrane-bound, or complex antigen targets.
Rationally improve antibody lead affinity and biophysical properties.
Enhance TCR specificity, affinity, or stability for cell therapy applications.
Full human antibody discovery from naïve or immune yeast display libraries.
End-to-end antibody hit generation against challenging targets.
Improve expression, stability, or activity of protein leads through directed evolution.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
