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MemDX™ mPro Human SSTR5 Cell Line (CAT#: S01YF-1122-KX56)

Datasheet
This product is a stable cell line. It stably expresses Human SSTR5 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • SSTR5
  • Target Protein Species
  • Human
  • Target Classification
  • GPCR
  • Target Family
  • Somatostatin Receptors
  • Target Research Area
  • Cancer Research; CNS Research
  • Related Diseases
  • Prolactinoma; Acromegaly

Product Properties

  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Somatostatin receptor 5
  • Introduction
  • Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.
  • GPCR Signaling Pathway
  • The endogenous ligand is Somatostatin. Targeted protein activation can cause binding of Gi to Go protein which, in turn, cause an inhibition of adenylate cyclase and then decrease of cAMP concentration.
  • G coupling
  • Gi & Go
  • Endogenous Ligand
  • Somatostatin
  • Alternative Names
  • SS-5-R; somatostatin receptor type 5; somatostatin receptor subtype 5; SSTR5; Somatostatin receptor 5

Case Studies

Customer reviews and Q&As    

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